CENTER OF EXCELLENCE FOR MATERIALS SCIENCE RESEARCH

由美国牙科协会健康协会在此提出的研究 基金会(ADAHF)的目的是(1)提供新的和改进的 作为牙科替代品的生物相容性牙科修复材料 汞合金；(2)开发一种涂层，它将提高 目前放置的银汞合金修复体；(3)开发合适的临床应用 成功使用的仪器、程序和指南 这些材料；以及(4)发展创新材料加工 战略和促进将这些技术转移到牙科 制造商和执业牙医。这种相互关联的， 多学科研究回应小灵通“健康人2000” 议程；对专门的材料科学研究中心的目标， 如RFA DE-93-001所述；以及国家 牙科研究所将发展改进、经济和 牙科汞齐的生物相容性替代品。在法庭作证时 众议院拨款小组委员会1993年3月，Harald Loe博士报告 研制了一种“无汞银汞合金原型”。这个 他提到的材料是由国家科学研究院的科学家发明的 标准与技术研究所(NIST)及其生存能力 在ADAHF英才中心的一个试点项目中演示 材料科学研究。材料的某些阶段进一步 开发现正由中心工作人员与 NIST的科学家，并建议在该项目上继续工作 应用程序(金属直销的合并和交付方法- 填充汞齐替代品)。还提议将该中心 研究小组开发了微晶玻璃镶件，以改善 1991年商业化推出的复合修复体的性能， 研究微晶玻璃材料的其他应用。 陶瓷修复材料)。建议将目前的中心 开发保护牙齿涂料的研究将扩展到 不仅用于牙冠和牙根的聚合物涂料粘合剂的研制 也适用于银汞合金及其替代物的修复 材料(用于防腐涂层和边缘修补的聚合物)； 目前中心在扩大单体方面的工作被重新定向到一个将军 复合体修复体应力降低的研究(减量) 聚合收缩和应力)；以及“合成牙本质” 正在由中心工作人员开发，以进一步探索各种 牙科和生物相容性测试应用(新型粘合剂 抗龋齿水泥)。

Research proposed herein by the American Dental Association Health Foundation (ADAHF) is intended to (1) provide new and improved biocompatible dental restorative materials as alternatives to dental amalgam; (2) develop a coating that will improve the efficacy of currently-placed amalgam restorations; (3) develop appropriate clinical instrumentation, procedures and guidelines for the successful use of these materials; and (4) develop innovating materials processing strategies and facilitate the transfer of these technologies to dental manufacturers and practicing dentists. This interrelated, multidisciplinary research is responsive to the PHS "Healthy People 2000" agenda; to the goals of Specialized Materials Science Research Centers, as stated in RFA DE-93-001; and to a major initiative by the National Institute of Dental Research to develop improved, economical and biocompatible alternatives to dental amalgam. In testimony before the House Appropriations Subcommittee in March 1993, Dr. Harald Loe reported the development of a "prototype mercury-free dental amalgam." The material to which he referred was invented by scientists at the National Institute of Standards and Technology (NIST) and its viability was demonstrated in a pilot project of the ADAHF's Center of Excellence for Materials Science Research. Some phases of the material's further development are now being conducted by Center staff in collaboration with NIST scientists, and continued work on this project is proposed in this application (Consolidation and Delivery Methods for a Metallic Direct- filling Amalgam Alternative). It is also proposed that the Center research team that developed glass-ceramic inserts to improve the properties of composite restorations, introduced commercially in 1991, investigate other applications of the glass-ceramic material (Glass- ceramic Restorative Materials). It is proposed that current Center research to develop protective tooth coatings be extended to the development of polymeric coatings adhesive not only to crown and root surfaces but also to restorations of amalgam and its alternative materials (Polymers for Preventive Coatings and Margin Repairs); that current Center work on expanding monomers be redirected toward a general investigation of stress reduction in composite restorations (Reduction of Polymerization Shrinkage and Stress); and that the "synthetic dentin" being developed by Center staff be further explored for a variety of dental and biocompatability testing applications (Novel Adhesive Cariostatic Cements).