BIOLOGY OF ALIMENTARY EPITHELIA IN HEALTH AND DISEASE

哈佛医学院和它的四个地理并列 附属医院，贝斯以色列，布里格姆和妇女，儿童医院 医院医疗中心和马萨诸塞州总医院已经加入 建立一个消化疾病中心， 结构与功能之间关系的有效研究 饮食技巧 这一主题最初是在深入分析 各成员院校在一年内的实力 为规划一个综合的 消化疾病中心 自中心成立以来，近4年 以前，人们不仅清楚地看到，选择这一主题是一个 很好的一个。 这五个机构中的每一个不仅拥有强大的 在细胞和分子水平的形态学程序，但有 也有一大群研究人员， 在消化道中的功能，其研究得到了极大的加强 通过与形态学家的合作。 几个新的和令人兴奋的 在过去的几年里， 中心的存在。 此外，它已变得越来越 很明显，消化道研究的各个领域 近年来，由于相关性不足， 结构和功能之间的关系。 互动与协作 临床医生（胃肠病学家、外科医生、病理学家）和基础 科学家强调。 若干核心资源有助于加强联合国的许多活动， 中心的调查员。 其中包括行政核心， 形态学、电生理学、脂质分析、蛋白质和 碳水化合物分析、电子探针分析、放射免疫分析和 以及其他各种现代免疫学技术。 一个广泛 丰富的方案，包括提供赠款， 试点/可行性研究，双周联合研究会议， 年度研讨会，命名为新的研究者奖，并有机会花 在我们自己以外的选定实验室进行短期实验 机构已提出。 该中心的长期目标是增进我们对 和消化系统疾病的知识，从而提高护理 患者有这些条件。 我们相信， 通过促进基础和临床的互动和合作， 科学家们致力于扩大生理学研究的范围， 生理相关，反之亦然。

The Harvard Medical School and four of its geographically juxtaposed affiliated hospitals, the Beth Israel, Brigham and Women's, Children's Hospital Medical Center, and Massachusetts General Hospital, have joined to establish a digestive disease center whose major emphasis is the more effective study of relationships between structure and function in the alimentary tact. This theme initially emerged from an in-depth analysis of the strengths of the component institutions during the period of an exploratory grant awarded for the purpose of planning an integrated digestive disease center. Since inception of the Center, almost 4 years ago, it has not only become clear that the choice of this theme was an excellent one. Each of the five institutions not only has strong programs in morphology at the cellular and molecular level, but there is also a large group of investigators with active programs to study function in the alimentary tract whose research is strongly potentiated by collaboration with morphologists. Several new and exciting collaborations have already been formed during the past several years of the existence of the Center. Furthermore, it has become increasingly evident that a variety of areas in alimentary tract research have suffered seriously in recent years because of inadequate correlations between structure and function. Interaction and collaboration between clinicians (gastroenterologists surgeons, pathologists) and basic scientists is emphasized. Several core resources serve to enhance the many activities of the investigators of the Center. These include an administrative core, and resources for morphology, electrophysiology, lipid analysis, protein and carbohydrate analysis, electron microprobe analysis, radioimmunoassay and a variety of other modern immunologic techniques. An extensive enrichment program including the availability of grants for pilot/feasibility studies, bi-weekly combined research conferences, annual symposia, named new investigator award, and opportunities to spend short periods of time in selected laboratories outside our own institutions has been proposed. The long-term objectives of this center are to enhance our understanding and knowledge of digestive diseases, and thereby improve the care of patients with these conditions. We believe that this can be accomplished by furthering the interaction and collaboration of basic and clinical scientists working to expand the scope of physiological research with moprhologic correlates, and vice versa.