Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology

这项建议旨在通过接触、流行病学和毒理学/毒物基因组学研究的综合，对空气污染对心肺健康的影响进行全面评估。我们将对人们暴露在空气污染中的情况进行详细评估，估计长期和短期流行病学分析的暴露程度，并将这些评估与基于队列研究的长期健康影响的流行病学分析、基于小组研究的短期影响(即生物标记物、血压、心率、峰值流量)以及基于出生队列的早期生活影响联系起来。此外，我们通过设计一项干预研究来测试减少暴露在细颗粒物而不是气体中的效果，其中志愿者将戴上口罩，并检查暴露-反应关系，与我们在小组研究中评估的短期影响相同。我们在流行病学研究中进行的短期生理测量将有助于深入了解空气污染影响心肺健康的机制。为了补充对作用机制的以人为基础的研究，我们的项目还将对机制效应和早期生命毒性基因组学/代谢组学进行广泛的体内分析。最后，我们将根据我们的研究结果，通过评估在健康风险评估中控制暴露于户外健康保护的选定策略的潜在价值，向利益攸关方提供实用建议。

This proposal aims to do a comprehensive evaluation of air pollution health impacts on cardiopulmonary health through integration of exposure, epidemiology, and toxicology/toxicogenomic studies. We will do detailed assessments of people's exposure to air pollution, estimating exposures for long- and short-term epidemiological analyses, and linking these to epidemiological analyses of long term health impacts based on a cohort study, short-term effects (i.e. biomarkers, blood pressure, heart rhythm, peak flow) based on a panel study, and early life effects based on a birth cohort. Additionally, we test the effect of reducing exposure to fine particles, but not gases, by designing an intervention study where volunteers will wear a face mask and examining the exposure-response relationship for the same short-term effects we evaluate in the panel study. The short-term physiological measurements we conduct in the epidemiological studies will provide insight into the mechanisms by which air pollutions affects cardiopulmonary health. To complement the human based studies into mechanisms of action, our project will also conduct extensive in vivo analyses of mechanistic effects, and early life toxicogenomics/metabonomics. Finally, we will provide practical advice to stakeholders based on our study findings, by assessing the potential value of selected strategies for control of exposure to outdoor health protection in a health risk assessment.