CORE--INFORMATICS SUPPORT

续订应用程序的信息学支持将扩展 为支持试剂开发的信息管理基础设施 在原始的CHLC应用程序中生成和构建地图。这个 INFORMATLCS的核心目标是提供基于计算机的工具 以促进该中心的科学目标。它的责任 包括试剂的储存、检索和解释，以及 在拟议的研究中产生的数据。这个核心的主要关注点是 开发和维护“生产”数据库(及其 支持应用程序)。其他职责包括正在进行的 开发和维护公共获取信息系统。这 系统提供了便利中心的沟通的工具 将资源映射到外部遗传学社区。《信息》 核心还负责管理所有的计算机资源 由中心提供支持。 在下一个供资周期内，InFORMATlCS核心将延长 用于生成、维护和分发人力资源的现有工具 基因图谱及其相关数据。重点工作将集中在 扩展当前的信息管理工具，以支持 公众产生的核苷酸多态的研究进展 可用的序列数据。核心还将开发数据捕获和 便利人口分布的管理工具 多态信息。InFORMATlCS核心还将扩展CHLC “虚拟实验室”信息管理系统。工具将是 开发用于从扩展的CEPH协作和 非CEPH家庭资源。目前正在使用的“公共服务器”工具 将扩展到包括双等位基因多态的识别 以及允许用户定义的有限区域的地图构建 飞翔“。

The informatics support for the renewal application will extend the information management infrastructure developed to support reagent generation and map construction in the original CHLC application. The objective of the INFORMATlCS CORE is provision of computer based tools that facilitate the scientific aims of the Center. Its responsibilities include the storage, retrieval, and interpretation of the reagents and data generated in the proposed research. A primary focus of this core is the development and maintenance of a "production" database (and its supporting applications). Additional responsibilities include the ongoing development and maintenance of a public access information system. This system provides tools that facilitate the communication of the Center's mapping resources to the outside genetics communities. The INFORMATlCS CORE is also responsible for the management of all the computer resources supported by the Center. During the next funding cycle the INFORMATlCS CORE will extend the existing tools for the generation, maintenance, and distribution of human genetic maps and their associated data. Key efforts will focus on the extension of current information management tools to support the development of nucleotide-based polymorphisms generated from publicly available sequence data. The CORE will also develop data capture and management tools to facilitate the distribution of population-based polymorphism information. The INFORMATlCS CORE will also extend the CHLC "virtual laboratory" information management system. Tools will be developed to capture genotype data from extended CEPH collaboration and non-CEPH family resources. The "public-server" tools currently in place will be extended to include identification of bi-allelic polymorphisms and to permit user defined map construction of limited regions "on-the- fly".