SCOR--MOLECULAR GENETICS OF HYPERTENSION

申请提出建立专门的研究中心 (SCOR)在爱荷华州大学高血压的分子遗传学研究 心血管中心。这一倡议，我们一直在计划 18个月，汇集了一批新的调查人员，包括 杰出的分子遗传学家(爱荷华州的Val Shefffield和Curt Sigmund 和俄亥俄州的John Rapp)；遗传流行病学家和生物统计学家 (特鲁迪·伯恩斯)；高血压生理学家(杰拉尔德·迪博纳，约翰·斯托克斯， 加里·鲍姆巴赫、让·罗比拉德、大卫·梅里尔和艾琳·马克 高血压分子遗传学SCOR计划的三个主要目标。 这项建议的优点包括： 1)对包括核心家庭在内的三个不同的人类群体的研究 来自马斯卡廷肥胖症和血压的人群研究；贝都因人 来自以色列南部同质人口的家庭 肥胖症和高血压的发病率；以及全州妇女网络 先兆子痫； 2)由Val领导的核心人类分子遗传学实验室 具有高通量基因分型便利能力的谢菲尔德 全基因组搜索； 3)染色体数量性状基因座的协同追寻 大鼠心力衰竭模型的生理和细胞中间表型 遗传性盐敏性高血压；以及 4)组织特异性基因表达和敲除在转基因中的应用 小鼠测试组织特异性肾素-血管紧张素系统在 高血压。 我们SCOR的调查人员，包括俄亥俄州的John Rapp，已经 建立了积极的合作和密切的互动。此外, 我们SCOR的调查人员还建立了广泛的 与其他研究人员在高血压遗传学方面的合作。 这一领先的分子遗传学家和高血压的联盟 爱荷华州SCOR的生理学家承诺 对提高分子遗传学知识的贡献 高血压。

The application proposes to establish a Specialized Center of Research (SCOR) in the Molecular Genetics of Hypertension in the University of Iowa Cardiovascular Center. This initiative, which we have been planning for 18 months, brings together a new cadre of investigators including outstanding molecular geneticists (Val Sheffield and Curt Sigmund at Iowa and John Rapp in Ohio); a genetic epidemiologist and biostatistician (Trudy Burns); and hypertension physiologists (Gerald DiBona, John Stokes, Gary Baumbach, Jean Robillard, David Merrill and Allyn Mark) to pursue the three broad goals of the Hypertension Molecular Genetics SCOR program. The strengths of the proposal include: 1) study of three distinctive human populations including nuclear families from the Muscatine population study of obesity and blood pressure; Bedouin families from a homogeneous population in Southern Israel with a high incidence of obesity and hypertension; and a statewide network of women with preeclampsia; 2) a lcading core human molecular genetics laboratory directed by Val Sheffield with capability for high throughput genotyping facilitating genome wide searches; 3) coordinated pursuit of chromosomal quantitative trait loci and physiologic and cellular intermediate phenotypes in rat models of genetically salt-sensitive hypertension; and 4) the use of tissue specific gene expression and knockouts in transgenic mice to test the role of tissue-specific renin-angiotensin systems in hypertension. The investigators in our SCOR, including John Rapp in Ohio, have established active collaborations and intense interaction. In addition, the investigators in our SCOR have also established extensive collaborations with other investigators in the genetics of hypertension. This coalition of leading molecular geneticists and hypertension physiologists in the Iowa SCOR holds promise for a substantial contribution to advancing knowledge of the molecular genetics of hypertension.