CORE--PATIENT ASSESSMENT, DATA ANALYSIS/MANAGEMENT

这个Rett中心核心的目标是：1)协调和联合 将单个项目转化为综合研究计划项目，2) 促进圆满完成拟议的具体目标 项目，以及3)启动未来的设计和开发 项目。核心将确保研究计划的整合 通过促进个人之间的动态交互，将项目作为一个整体 调查人员和其他科学家，特别是我们的外部 顾问。这些互动将促进和确保 共享信息，批判潮流，研究计划项目 研究努力，并制定新的假设和研究设计。这个 本计划项目的研究工作将由 核心成员包括格雷泽博士、阿姆斯特朗博士、邓恩博士和邓恩女士。 舒尔茨，他们中的大多数人都参与了这个研究项目 自成立以来，确保了我们研究工作的连续性。 核心是患者识别、教育、随访的中心 和研究方案注册。核心成员将提供 对一个庞大的、定义明确和既定的小组进行纵向评估 RS患者，从而提供临床资料以与 单个项目的研究努力。在他的指导下， 该核心提供统计设计和分析支持以及 继续开发已有的、经常使用的数据库 不仅用于识别和选择患者，而且还用于 假设的生成。核心的这些活动确保了一体化 通过将我们的 多学科团队要综合研究多个维度 RS。

The goal of this Rett Center Core is: 1) to coordinate and unite the individual Projects into an integrated Research Program Project, 2) to facilitate the successful completion of the specific aims of the proposed projects, and 3) to initiate the design and development of future projects. The Core will ensure the integration of the Research Program Project as a whole by promoting dynamic interactions among individual investigators and with other scientists, particularly our External Advisors. These interactions will promote and ensure the growth of the Research Program Project by sharing information, critiquing current research efforts, and formulating new hypotheses and research designs. The research efforts of this Program Project will be closely monitored by members of the Core that include Drs. Glaze, Armstrong, Dunn, and Ms. Schultz, most of whom have been involved in this Research Program Project since its inception, and ensure the continuity of our research efforts. The Core is the center for patient identification, education, follow-up and research protocol enrollment. Members of the Core will provide longitudinal assessment of a large, well defined and established group of RS individuals, thereby providing clinical profiles to correlate with the research efforts of the individual projects. Under the direction of Dr. J.K. Dunn, the Core provides statistical design and analysis support and continues to develop an already extensive data base that is used regularly not only for patient identification and selection, but also for the generation of hypotheses. These activities of the Core ensure integration of the Research Program Project as a whole by bringing together our multidisciplinary team to study in an integrated the many dimensions of RS.