权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Rare Disease Sleep Pilot Research Plan

罕见疾病睡眠试点研究计划

基本信息

批准号：
8153422
负责人：
DANIEL G. GLAZE
金额：
$ 27.08万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8153422
关键词：
Adenoidectomy Adult Adverse effects Age Angelman Syndrome Anxiety Behavior Behavior Therapy Behavioral Brain Bruxism Child Chronic Disease Circadian Rhythms Clinic Clinical Cognitive Confusional Arousals Data Development Disease Evaluation Family Genotype Health Impairment Incentives Individual Intervention Interview Iron Lead Learning Life Cycle Stages Longitudinal Studies Medical Medicine Melatonin Memory Mentally Disabled Persons Nature Neuronal Plasticity Night Terrors Obstructive Sleep Apnea Oral Participant Performance Pharmaceutical Preparations Pilot Projects Polysomnography Population Prader-Willi Syndrome Prevalence Quality of life Questionnaires Rare Diseases Recruitment Activity Research Resistance Rett Syndrome Risk Role Severities Site Sleep Sleep Apnea Syndromes Sleep Disorders Sleep disturbances Sleeplessness Somatotropin Somnambulism Specialist Syndrome Tonsillectomy Treatment outcome base effective therapy high risk hormone therapy improved limb movement nervous system disorder neurogenesis novel diagnostics sleep abnormalities standard of care treatment strategy

项目摘要

VII.iii. Rare Disease Sleep Pilot Research Plan A. Introduction: The importance of sleep to proper health has emerged in recent years. The range of sleep disorders in children is broad, although the relevance of sleep to normal development and chronic illness is not well understood. Recently, critical roles for sleep in learning, memory, neurogenesis, and neural plasticity have been described, underlying the importance of sleep to brain function and brain development[1]. Consistently, sleep disturbances (sleep apnea, insomnia, sleepwalking, night terrors, confusional arousals, periodic limb movements (PLMS), and bruxism) have significant adverse effects on the quality of life of children and their families. Individuals with neurological disease are at particular risk because sleep disruptions lead to exacerbation of daytime behaviors and result in poor cognitive performance[2]. It is important to understand the nature of sleep impairments in children with neurological disorders, since this may have important implications for the degree of impairment of quality of life and intellectual functioning. Any understanding between sleep problems and behavioral disturbances would aid such understanding. The prevalence of sleep problems in the normal population is estimated to be between 18-37% in different Studies[3,4]. Questionnaire and interview based studies among mentally retarded subjects show that approximately 15-50% of adults and 30-67% of children have sleep problems5'6 There are very little data on sleep abnormalities in Angelman syndrome (AS), Rett syndrome (RTT), and Prader-Willi syndrome (PWS).

VII.iii.罕见疾病睡眠试点研究计划 A.简介：睡眠对健康的重要性近年来逐渐显现。睡眠障碍的范围儿童是广泛的，尽管睡眠与正常发育和慢性疾病的相关性不是很好明白最近，睡眠在学习、记忆、神经发生和神经可塑性中的关键作用已经被发现。睡眠对大脑功能和大脑发育的重要性[1]。我们一贯认为，睡眠障碍（睡眠呼吸暂停、失眠、梦游、夜惊、意识模糊觉醒、周期性肢体运动（PLMS）和磨牙症）对儿童的生活质量及其家庭患有神经系统疾病的人特别危险，因为睡眠中断会导致日间行为加剧，导致认知能力差[2]。重要的是要了解神经系统疾病儿童睡眠障碍的性质，因为这可能具有重要意义生活质量和智力功能受损的程度。在睡眠和睡眠之间问题和行为障碍将有助于这种理解。正常人群中睡眠问题的患病率估计在18-37%之间，研究[3，4]。对智力落后者的问卷调查和访谈表明，大约15-50%的成年人和30-67%的儿童有睡眠问题5 '6 Angelman综合征（AS）、Rett综合征（RTT）和Prader-Willi综合征（PWS）的睡眠异常。