CORE--GERIATRIC CLINICAL PSYCHOPHARMACOLOGY

本核心关注抗抑郁药研究， 用去甲替林和帕罗西汀测定血小板5-HT重摄取 使用抗抑郁药物中断，包括双- 帕罗西汀的盲法研究，一种有效的新型5-羟色胺再摄取抑制剂 与更常用的去甲替林相比。 这项研究的目的是 记录老年人的药代动力学变化。 一个主要目标是 本核心是为其他核心和相关 研究者的项目侧重于药代动力学/药效学 评估，并为学生和地区提供相关指导 疗养院，体内（表型分析）和体外（药物代谢测定） 细胞色素P450功能的研究，一种负责代谢的酶 抗抑郁药的副作用

This Core focuses on antidepressant studies and is particularly concerned with the assay of nortriptyline and paroxetine platelet 5-HT reuptake interrupted by the use of antidepressant medication, including a double- blind study of paroxetine, a potent innovative serotonin reuptake inhibitor versus the more generally used nortriptyline. The goal of the study is to document pharmacokinetic changes in elderly adults. one primary goal of the present Core is to provide support for other cores and relevant projects of the investigators focused on pharmacokinetic/pharmacodynamic assessments, and to provide relevant instruction for students and area nursing homes, in vivo (phenotyping) and in vitro (drug metabolic assays) studies of cytochrome P450 function, an enzyme responsible for metabolism of significant antidepressants.