NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY/REPAIR

该中心的主题是“增强组织的新策略 完整性和修复。“两种互补的方法将是 其次：加强颅面组织的修复， 发育或后天缺陷;并进行干预， 这些组织的破坏和退化。 对于组织修复， 基本假设是正常的组织分化和成熟， 组织重塑和修复过程 机械特征。 我们的目标是找出正常的 发展和功能，并制定新的战略，刺激 再生修复 发育或后天矿化 缺陷，目的是增加组织形成。 基本前提 是因为许多颅面组织 发育和退化性疾病是可以预防的。 因此 诊断、风险评估、干预和教育推广 可以采取一些措施来减少这些疾病的发生率和发病率， 紊乱 规划补助金的目的是加强互动 在基础、临床、社会和临床科学家中， 研究、治疗方法、预防和外联战略 可能出现的问题;最后选定将列入 最终提案;获取潜在患者的初步数据 风险评估、诊断、结局中使用的人群 和教育研究;并建立联系， 促进与学术界、工业界和 北方地区的社区机构和资源 加州。 项目开发期将用于： 行政结构;为最后提案选择项目; 发展生物统计核心设施;扩大和发展与 区域研究机构和公司;扩大关系 与区域健康维护组织和健康保险公司合作; 制定临床科学家和卫生保健教育计划 预防、干预和治疗战略的提供者; 一个全球性的交流网站;并扩大筹款活动 能力，并制定一个程序， 资金

The theme of this center is "New strategies for enhancing tissue integrity and repair." Two complementary approaches will be followed: enhancing the repair of craniofacial tissues with developmental or acquired defects; and intervening to prevent the destruction and degeneration of these tissues. For tissue repair, the basic hypothesis is that normal tissue differentiation and maturation, and tissue remodeling and repair processes share important mechanistic features. The goal is to uncover markers for normal development and function, and develop novel strategies for stimulating regenerative repair. For developmental or acquired mineralization defects, the aims is to augment tissue formation. The basic premise for the maintenance of tissue integrity is that many craniofacial developmental and degenerative disorders are preventable. Thus diagnostic, risk-assessment, intervention and educational outreach strategies could be used to reduce the incidence and morbidity of these disorders. The aims of the planning grant are to enhance interactions among basic, clinical, social and clinical scientists so that new ideas for research, treatment approaches, prevention and outreach strategies may emerge; to make a final selection of projects to be included in the final proposal; to obtain preliminary data on potential patient populations to be used in the risk-assessment, diagnostic, outcomes and educational studies proposed; and to establish linkages that will foster productive interactions with the academic, industrial and community institutions and resources in the area of northern California. The project development period would be used to: develop the administrative structure; select the projects for the final proposal; develop a biostatistics core facility; expand and develop ties with regional research institutions and corporation; expand relationships with regional health maintenance organizations and health insurers; develop plans for education of clinician scientists and health care providers in prevention, intervention and treatment strategies; develop a world-wide web site for communication; and to expand fund-raising capabilities as well as develop a process for allocating COHRCD funds.