IS SOCIAL DRINKING ASSOCIATED WITH INCREASED ISOPROSTANE PRODUCTION?

这项研究的目的是确定酒精的社会消费是否 与8-epi PGF 2 α（一种新的标记物）的形成增加有关 自由基催化的脂质过氧化反应。 自由基的产生是 与多种疾病有关。 在这方面的研究， 然而，在很大程度上显示了与自由贸易有关间接和间接的联系， 阅读与疾病 主要原因是， 用于量化自由基形成的技术。 在 此外，从动物研究中获得的大多数结果都在 血液中酒精含量超过200毫克/毫升。 本研究 旨在寻找人类产生自由基的证据， 测量8 epi-PGF 2 α，响应于较少量的 酒精 研究人员打算扩大这项研究，以探索 脂肪酸消耗量、社会酒精摄入量和游离脂肪酸之间的相互作用 用这些试验数据进行激进的生产。

The aim of this study is to determine if social consumption of alcohol is associated with increased formation of 8-epi PGF 2 alpha, a novel marker of free-radical catalyzed lipid peroxidation. Free radical generation is implicated in a wide variety of disease states. Research in this area, however, has shown largely indirect and cirumstantial association of free readicals and disease. The main reasons for this has been the inadequacy of the techniques employed to quantify free radical formation. In addition, most of the results obtained from animal studies are in the setting of blood alcohol levels in excess of 200 mg/ml. This study is designed to look for evidence of free radical generation in humans, by measurement of 8 epi-PGF 2 alpha, in response to smaller amounts of alcohol. The investigators intend to expand the study to explore the interaction between fatty acid consumption, social alcohol intake and free radical generation with these pilot data.