CANCER CACHEXIA

体重减轻预示着癌症患者预后不佳。我们 假设这种体重减轻是休息增加的函数 能量消耗(REE)和厌食症，这是由 白介素1(IL-1)、白介素6(IL-6)、肿瘤坏死因子(TNF)。 我们建议通过测量稀土元素、身体成分、 可切除非小细胞肺癌患者的饮食摄入量和细胞因子水平 根治性切除前后的细胞癌。我们建议 将这些参数与健康的、匹配的对照组中的参数进行比较以进行测试 这一假设是通过测量稀土元素、身体成分、饮食摄入量和 可切除非小细胞癌患者细胞因子水平的变化 根治性切除前后。我们建议将它们进行比较 这些参数被认为是健康的、匹配的对照组。此外，我们 建议控制抑郁症及其对这些疾病的可能影响 通过让受试者完成抑郁问卷来确定参数。最后， 我们计划在肿瘤内寻找这些细胞因子的存在。 用免疫组织化学方法对切除的肿瘤标本进行检测。

Weight loss predicts a poor prognosis in the patient with cancer. We hypothesize that this weight loss is a function of increased resting energy expenditure (REE) and anorexia and that it is driven by interlukin-1 (Il-1), interlukin-6 (IL-6), and tumor necrosis factor (TNF). We propose to test this hypothesis by measuring REE, body composition, dietary intake, and cytokine levels in patients with resectable non-small cell cancer both before and after curative resection. We propose to compare these parameters to those seen in healthy, matched control to test this hypothesis by measuring REE, body composition, dietary intake, and cytokine levels in patients with resectable non-small cell cancer both before and after curative resection. We propose to compare these parameters to those seen healthy, matched controls. In addition, we propose to control for depression and its possible effect on these parameters by having subjects complete depression questionaires. Finally, we plan to look for the presence of these cytokines within the tumor itself by using immunohistochemical methods on resected tumor specimens.