NICOTINE ON SENSORY GATING OF AUDITORY EVOKED POTENTIALS IN MAN

患者将分两次入住CRC一天 场合患者将在实验当天上午NPO入院。 将开始静脉注射生理盐水，定期采集血液样本， 在白天的晚些时候服用。病人将被给予 阿德勒医生的身体检查 的 在静脉注射后，患者将安静地躺30分钟， 进行体检。然后病人会被唤醒 然后记录电位。然后患者将接受神经生理学检查， 由调查小组进行的测试。患者将在 给予尼古丁口香糖或安慰剂咀嚼5分钟，然后吐出 出去 如果患者是不吸烟的正常对照，不服用抗精神病药物 药物，他们将给予60毫克-90毫克的proanthaline之前， 用安慰剂或尼古丁口香糖治疗。10分钟，60分钟， 120分钟的周期，诱发电位记录，神经心理学测试和 血液会重复。

Patients will be admitted to the CRC for one day on two separate occasions. Patients will be admitted NPO in he morning of the experiment. An IV will be started with saline from which periodic blood samples will be taken at later time points during the day. The patient will be giv en a physical examination by Dr. Adler before the protocol is started. The patient will lie quietly for 30 minutes after the IV is put in and physical exam is administered. The patient will then have her evoked potentials are then recorded. The patient will then have neurophyscology tests administered by the investigative team. The patient will then be given either nicotine gum or placebo to chew for 5 minutes and then spit out. If the patient is a non smoking normal control not on neuroleptic medication, they will be given 60 mg-90 mg of propanthaline prior to treatment with either placebo or nicotine gum. 10 minute, 60 minute and 120 minute periods, evoked potential recording, neuropsychology tests and blood will be repeated.