Do ‘classical’ or ‘oxidative’ UVR-induced DNA adducts drive melanoma induction after ultraviolet radiation

关于阳光照射影响黑色素瘤发展的机制还存在争议。这导致在制定足够的防晒霜和安全暴露水平指南方面存在困难。我们将阐明紫外线诱导的DNA加合物是多发性骨髓瘤发育所必需的。这将把实验证据引入关于阳光暴晒和黑色素瘤的辩论中。晒伤后使用含有酶的面霜可以迅速去除危险的DNA加合物。

There is debate about the mechanisms by which sun exposure influences melanoma development. This leads to difficulties in formulating adequate sunscreens and guidelines for safe levels of exposure. We will elucidate the critical UV-induced DNA adducts that are necessary for MM development. This will introduce experimental evidence into the debate about sun exposure and melanoma. The use of post sunburn creams containing enzymes which rapidly remove the dangerous DNA adducts will be indicated.