Discovery of New and Better Treatments for Human African Trypanosomiasis

昏睡病或非洲锥虫病存在于36个国家，有6 000万人面临感染风险，每年有50 000 - 70 000例新病例和48 000例死亡。通过采采蝇的叮咬传播，这种疾病是由原生动物寄生虫布氏锥虫引起的，如果不治疗，死亡是不可避免的。我们已经发现了一些对布氏锥虫有微弱抑制作用的化合物，本项目的目的是使它们足够有效，成为候选药物。

Sleeping sickness, or human African trypanosomiasis, is present in 36 countries where there are 60 million people at risk of infection, with 50,000-70,000 new cases and 48,000 deaths per annum. Transmitted by the bite of the tsetse fly, this disease is caused by the protozoan parasite Trypanosoma brucei, and without treatment, death is inevitable. We have discovered some compounds that weakly inhibit T.brucei and the aim of this project is to make them potent enough to become drug candidates.