Discovery of New and Better Treatments for Human African Trypanosomiasis

昏睡病或非洲人类锥虫病存在于36个国家，这些国家有6000万人面临感染风险，每年有5万至7万新发病例和4.8万例死亡。这种疾病由采采蝇叮咬传播，是由原生动物寄生虫布鲁氏锥虫引起的，如果不治疗，死亡是不可避免的。我们已经发现了一些弱抑制布鲁氏杆菌的化合物，这个项目的目的是使它们足够有效，成为候选药物。

Sleeping sickness, or human African trypanosomiasis, is present in 36 countries where there are 60 million people at risk of infection, with 50,000-70,000 new cases and 48,000 deaths per annum. Transmitted by the bite of the tsetse fly, this disease is caused by the protozoan parasite Trypanosoma brucei, and without treatment, death is inevitable. We have discovered some compounds that weakly inhibit T.brucei and the aim of this project is to make them potent enough to become drug candidates.