HPA AXIS FUNCTION AND HIPPOCAMPUS IN WOMEN WITH SEXUAL ABUSE RELATED PTSD
HPA AXIS FUNCTION AND HIPPOCAMPUS IN WOMEN WITH SEXUAL ABUSE RELATED PTSD
批准号:
6116055
负责人:
James Douglas Bremner
金额:
$3.45万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30
中文摘要
本研究旨在探讨女性创伤后应激障碍(PTSD)与儿童期性虐待相关的下丘脑-垂体-肾上腺轴(HPA)功能及海马体的变化。这项研究将包括用核磁共振测量海马体体积,用神经心理测试评估记忆功能,24小时测量血浆皮质醇、ACTH和β-内啡肽,进行CRF和ACTH激发试验,并使用地塞米松来测量记忆功能。目前正在分析数据。
英文摘要
The purpose of this study is to measure the hypothalamic-pituitary-adrenal axis (HPA) function and the hippocampus in women Posttraumatic Stress Disorder (PTSD) related to childhood sexual abuse. The study will entail measurement of hippocampal volume with MRI, assessment of memory function with neuropsychological testing, 24 hour measurement of plasma cortisol, ACTH and Beta-endorphin, a CRF and ACTH challenge test and administration of dexamethasone with measurement of memory function. Data is currently being analyzed.
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海外基金