课题基金 / 基金详情

HUMAN METHIONINE AND HOMOCYSTEINE METABOLISM

HUMAN METHIONINE AND HOMOCYSTEINE METABOLISM
人类蛋氨酸和同型半胱氨酸代谢
批准号：
6115977
负责人：
NAOMI K FUKAGAWA
金额：
$3.29万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115977
关键词：
5,10 methylenetetrahydrofolate aminoacid metabolism cystathionine beta synthase enzyme deficiency gender difference gene mutation homocysteine human subject methionine oxidoreductase transmethylation

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中文摘要
翻译
该项目的主要目标是量化没有维生素B6、B12或叶酸缺乏证据的健康男性和女性的转甲基化、再甲基化、转硫作用和半胱氨酸周转率，并以亚甲基四氢叶酸还原酶和胱硫醚合酶的基因突变为特征，其次，以确定蛋氨酸代谢是否存在明显的性别差异，从而解释绝经前妇女中高半胱氨酸水平较低的报道。 在本报告所述期间，对16名受试者进行了研究。 所有患者均对研究耐受良好。计划：继续招募志愿者。
英文摘要
The major goals of this project are to quantify rates of transmethylation, remethylation, transsulfuration, and cysteine turnover in healthy men and women without evidence of vitamin B6, B12 or folate deficiency and characterized for genetic mutations in methylenetetrahydrofolate reductase and cystathionine (-synthase, and secondly, to determine whether or not apparent gender differences in methionine metabolism do exist thereby accounting for the reportedly lower homocysteine levels in premenopausal women. Sixteen subjects were studied during the reporting period. All tolerated the studies well. Plan: To continue recruitment of volunteers.
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