GENETIC LINKAGE STUDY OF OTITIS MEDIA

单个中耳炎(OM)发作的频率如此之高，以至于不太可能识别出遗传易感性。然而，急性中耳炎(AOM)反复发作和持续性中耳积液(MEE)的易感性可能有重要的遗传成分。本研究的研究设计为同胞配对连锁研究。我们最近对OM的一项双胞胎/三胞胎研究估计，中耳疾病的易感性在两岁时的遗传率约为0.72。这表明，通过对受影响同胞对的遗传标记进行全基因组筛查和体面身份(IBD)分析，确定导致易感性的一个或多个主要基因是可行的。这项拟议的研究将招募200对受影响的兄弟姐妹及其可用的父母样本，以识别易感基因。由于偶然的原因，这些父母被招募来区分IBD的标记等位基因和按状态识别。

The frequency of a single episode of otitis media (OM) is so high that a genetic predisposition is unlikely to be identified. However, the predisposition to recurrent episodes of acute otitis media (AOM) and to persistent middle ear effusion (MEE) may have a significant genetic component. The research design for this study is a sibling-pair linkage study. We have recently estimated for a twim/triplet study of OM that the susceptibility to middle ear disease has a heritability of approximately 0.72 by two years of age. This suggests that it is feasible to identify a major gene or genes contributing to susceptibility using a genome-wide screen of genetic markers in affected sibling pairs and identity-by-decent (IBD) analysis. The proposed study will recruit a sample of 200 affected sibling pairs and their available parents for the identification of susceptibility genes. The parents are being recruited to distinguish IBD for marker alleles from identify-by-state due to chance.