PILOT STUDY OF ACUTE TOLERANCE TO ALCOHOL USING BAC CLAMPING OF 80MG%

为提交酒精研究中心(ARC)更新做准备 申请，12/96，建议进行初步研究：对几个受抚养人 测量大脑功能，恢复到基准值，而 呼气酒精浓度(BRAC)保持在80%将被检查。 BAC夹闭使用口服负荷量和静脉注射的组合 林格氏乳酸中注入乙醇建立和维持BR-AC 在目标水平上。我们已经进行了类似的IRB批准的试验 过去四年在IUSM的学习，以及寻求 IRB对这项研究的单独审查基于以下变化。(1) 夹具的目标水平将为80%，而之前的目标水平为50% 学习。(2)从属测量包括行为测量和 神经心理测量除事件相关的专利和 我们过去采用的主观高评价量表措施。 (3)受试者群体来自遗传学方面的合作 酗酒人口的比例。本研究的具体目的是 在ARC中建议的样本总体中论证可行性 应用，以量化急性耐受性的酒精在80毫克%溴AC， 提供数据以估计ARC所需的样本量 建议建立ERP和SHAS的测试/复测可靠性 检查PR和N-Psy的敏感性 为了敏锐的耐受性。

In preparation for submission of the Alcohol Research Center (ARC) renewal application, 12/96, a pilot study is proposed: for several dependent measures of brain function, recovery towards baseline values while the breath alcohol concentration (BrAC) is maintained at 80% will be examined. BrAC clamping uses a combination of an oral loading dose and intravenous infusion of ethanol in Ringer's lactate to establish and maintain a Br AC at the target level. We have conducted similar, IRB-approved pilot studies at IUSM over the last four years, and the rationale for seeking separate IRB review of this study is based on the following changes. (1) The target level of the clamp will be 80%mg, compared to 50mg% in previous studies. (2) The dependent measures include a behavioral measure and neuropsychological measures in addition to the event-related patential and subjective high assessment scale measures we have employed in the past. (3) the subject population is drawn from the collaboration on the genetics of alcohol population. The specific aims of the present study are to demonstrate feasibility in the sample population to be proposed in the ARC application, to quantify acute tolerance to alcohol at 80mg% Br AC, providing data for estimating the sample size required in the ARC proposal, to establish the test/retest reliability of ERP and SHAS measures at 80mg% and to examine PR and N-Psy measures for sensitivity to acute tolerance.