METABOLIC & HORMONAL IMPACT OF BINGE EATING IN NORMAL WOMEN--PILOT STUDY

这是一项初步研究，以确定最佳长度的饮食 干预后续研究。研究对象是普通女性 在两个连续月经周期的早期卵泡期。 女性将进入GCRC接受3天的控制饮食， 这将包括要么三餐加零食每天，或相同的 一个晚上每天摄入的维持体重的卡路里数 餐在每种饮食的第三天，每个受试者将经历24小时 每15分钟一次，频繁采血检测血糖和胰岛素。每个 女性将接受20分钟的胰岛素耐量试验， 出院前的早晨受试者将在 在卵泡早期后，对于相反的相同方案， 饮食.每天收集24小时尿液， 入院通过尿皮质醇和儿茶酚胺评估应激 程度.六到八名正常妇女将在这个试点研究， 确定三天的控制饮食是否足以诱导 胰岛素水平的变化。随后，适当的研究长度 将用于高雄激素和糖尿病妇女的未来研究 沿着附加分析。

This is a pilot study to determine the optimal length of dietary intervention for subsequent studies. Normal women will be studied during the early follicular phase of two consecutive menstrual cycles. The women will be admitted to the GCRC for 3 days of a controlled diet, which will consist of either 3 meals plus a snack daily, or the same number of daily weight-maintenance calories given as a single evening meal. On the third day of each diet, each subject will undergo 24 hours of q15 minute frequent blood sampling for glucose and insulin. Each women will undergo a 20 minute insulin tolerance test on the following morning before discharge. The subjects will be readmitted in the following early follicular phase for the same protocol on the oppsite diet. Daily 24 hour urine collections will be made each day of each admission to evaluate stress by urinary cortisol and catecholamine levels. Six to eight normal women will be studied in this pilot to determine if three days of a controlled diet are sufficient to induce a change in insulin levels. Subsequently, the appropriate study length will be utilized in future studies of hyperandrogenic and diabetic women along with additional analyses.