EFFECT OF ORAL DHEA ON INSULIN SENSITIVITY & LH IN NORMAL WOMEN

肾上腺激素脱氢表雄酮（DHEA）及其硫酸盐 （DHEA-S）与胰岛素水平呈负相关， 心血管疾病、癌症、肥胖症和糖尿病。但 该协会的机制尚不清楚。胰岛素作为一种 DHEA/DHEA-S代谢生理调节剂;高胰岛素血症 降低正常受试者和多囊卵巢综合征妇女的血清DHEA-S 卵巢综合征（PCOS），同时增加雄烯二酮（D4-A）和 睾酮水平相反。的发散相关性 循环DHEA-S和睾酮/雄烯二酮联合 DHEA饮食效应的动物数据表明，DHEA-S和睾酮 因此可能对胰岛素分泌和作用产生相反的作用。

The adrenal hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) have been negatively correlated with insulin levels, cardiovascular morbidity, cancer, obesity and diabetes. However, the mechanism of the association is unclear. Insulin acts as a physiological regulator of DHEA/DHEA-S metabolism; hyperinsulinemia decreases serum DHEA-S in normal subjects and in women with polycystic ovary syndrome (PCOS), while increasing androstenedione (D4-A) and testosterone levels conversely. The divergent correlations of circulating DHEA-S and testosterone/adrostenedione combined with the animal data of diet effects of DHEA suggest that DHEA-S and testosterone may therefore exert opposing effects on insulin secretion and action.