Relationship between longevity marker and serum dehydroepiandrosterone sulfate in epidemiological study

流行病学研究中长寿标志物与血清硫酸脱氢表雄酮的关系

• 批准号: 23590904
• 负责人: ENOMOTO Mika
• 金额: $ 3.41万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590904/
• 关键词: 老年医学; 認知機能; 予防医学; 前向き研究

Dehydroepiandrosterone (DHEA) sulfate are secreted adrenal steroids. DHEAS concentrations decline with age. We investigated whether serum DHEAS levels could predict cognitive function in residents. The study was set as a prospective community-based cohort study. A total of 1940 subjects underwent a health examination in 2009. Serum DHEAS levels were measured by radioimmunoassay at baseline in all subjects, and they were periodically followed until 2014. Baseline DHEAS levels were higher in men than in women and decreased with age in both sexes.In multiple regression analyses adjusted for age and gender, the significance of inverse relationship between MMSE and DHEAS was still remained. This 5-year study in a community-based cohort indicated that DHEAS levels may be a predictor of cognitive function.

硫酸脱氢表雄酮（DHEA）是肾上腺分泌的类固醇。DHEAS浓度随年龄增长而下降。我们调查了血清DHEAS水平是否可以预测居民的认知功能。本研究是一项前瞻性社区队列研究。2009年，共有1 940人接受了健康检查。通过放射免疫测定法测量所有受试者基线时的血清DHEAS水平，并定期随访至2014年。DHEAS水平男性高于女性，且随年龄增长而下降，经年龄和性别校正后，MMSE与DHEAS呈负相关。 这项为期5年的社区队列研究表明，DHEAS水平可能是认知功能的预测因子。

项目成果

Urinary liver-type fatty acid binding protein is associated with microalbuminuria as well as insulin resistance in a general population

尿肝型脂肪酸结合蛋白与一般人群的微量白蛋白尿以及胰岛素抵抗相关

• 发表时间: 2013
• 作者: Fukami A;Adachi H;Hirai Y;Enomoto M;Otsuka M;Kumagae S;Nanjo Y;Yoshikawa K;Esaki E;Yokoi K;Ogata K;Tsukagawa E;Kasahara A;Ohbu-Murayama K;Obuchi A;Yoshimura A;Imaizumi T
• 通讯作者: Imaizumi T

A new measurement system of visceral fat area by bioelectrical impedance analysis in a population of community-dwelling Japanese

通过生物电阻抗分析测量居住在社区的日本人的内脏脂肪面积的新系统

• 发表时间: 2012
• 作者: Mika Enomoto;Hisashi Adachi;Yuji Hirai;Ako Fukami;Kuniko Yoshikawa;Eishi Esaki;Kinuka Ogata;Akiko Kasahara;Eri Tsukagawa;Kanako Yokoi;Sachiko Nakamura;Aya Obuchi;Ayako Yoshimura;Tsutomu Imaizumi
• 通讯作者: Tsutomu Imaizumi

Plasma fetuin-A levels is associated with insulin resistance in a general population.

血浆胎球蛋白-A 水平与普通人群的胰岛素抵抗相关。

• 发表时间: 2012
• 作者: Aya Obuchi;Hisashi Adachi;et al.
• 通讯作者: et al.

一般住民検診における内臓脂肪測定の意義

内脏脂肪测量在一般人群检查中的意义

• 发表时间: 2012
• 作者: 榎本美佳;足達寿;平井祐治;今泉勉
• 通讯作者: 今泉勉

High Level of Plasma Remnant-like Particle Cholesterol May Predispose to Development of Hypertension in Normotensive Subjects

• DOI: 10.1093/ajh/hpt011
• 发表时间: 2013-06-01
• 期刊: AMERICAN JOURNAL OF HYPERTENSION
• 影响因子: 3.2
• 作者: Kasahara, Akiko;Adachi, Hisashi;Imaizumi, Tsutomu
• 通讯作者: Imaizumi, Tsutomu