GCRC-CAP-STEPHANIE SEMINARA, MD

目前的建议是一项为期五年的竞争性续期申请，由 马萨诸塞州综合医院将支持其Mallinckrodt综合医院 临床研究中心(GCRC)。GCRC已经满足了临床的需要 调查人员在马萨诸塞州总医院工作了70多年 好几年了。它已经由美国国立卫生研究院资助了30年 五年，最初是作为代谢研究中心(NIAMD)，自1978年以来 综合临床研究中心(NCRR)。当前应用程序 请求1 934个病人床日(每个每日研究单位)和4 244个 门诊就诊。将利用这些资源的协议 代表分布在13个单位的65名研究人员的临床研究 MGH的6个部门。目前提交的文件继续扩大 在上一个5年周期内启动的GCRC利用率， 内分泌学、糖尿病和新陈代谢，越来越多的方案 精神病学、神经病学、传染病、肿瘤学和老年学 都包括在内。几乎所有的协议都是由调查员发起的 其中大部分是由NIH拨款支持的。 Mallinckrodt GCRC为广泛的临床 研究活动，特别是需要频繁、有时间的研究 血液和其他体液的收集，创新和复杂 诊断、治疗和生理技术，包括设施 对于基因治疗，仔细控制饮食，控制睡眠时间 或光环境。许多新的治疗方案包括那些 通常比过去研究的人病得更重。GCRC提供专家 护理，复杂的饮食和生物统计支持，以及 扩大核心实验室，以及其他必要的行政支持，以 进行临床调查。 GCRC非常积极地培训医生、护士、营养师和 临床调查中的学生。关于GCRC的教育工作 包括通过若干机制支持研究生培训 包括培训临床研究人员的CAP计划，由 已经启动了GCRC。 Mallinckrodt GCRC在临床上有着悠久的卓越历史 研究，并一直是临床有意义的进展的地点 医学已有60多年的历史。它将继续作为主要的 在MGH进行住院和门诊临床调查的地点。

The current proposal is a five year competitive renewal application by the Massachusetts General Hospital to support its Mallinckrodt General Clinical Research Center (GCRC). The GCRC has served the needs of clinical investigators at the Massachusetts General Hospital for more than 70 years. It has been funded by the National Institutes of Health for thirty five years, first as a metabolic research center (NIAMD) and since 1978 as a General Clinical Research Center (NCRR). The current application requests 1,934 patient bed days (per diem research unit) and 4,244 outpatient visits. The protocols that will utilize these resources represent clinical research from 65 investigators located in 13 units and 6 departments at the MGH. The current submission continues the expansion of GCRC utilization, initiated during the previous 5 year cycle, endocrinology, diabetes and metabolism, an increasing number of protocols from Psychiatry Neurology, Infectious Diseases, Oncology, and Gerontology are included. Almost all of the protocols are investigator initiated and the majority are supported by NIH grants. The Mallinckrodt GCRC provides facilities for a broad array of clinical research activities, particularly research requiring frequent, timed collections of blood and other bodily fluids, innovative and complex diagnostic, therapeutic and physiological techniques including facilities for gene therapy, careful control of diets, and controlled sleep schedules or light environment. Many of the new protocols include patients who are generally more ill than those studied in the past. The GCRC offers expert nursing care, sophisticated dietary and biostatistical support, an expanded Core Laboratory, and other administrative support necessary to perform clinical investigation. The GCRC is very active in training physicians, nurses, dieticians, and students in clinical investigation. The educational efforts on the GCRC include post-graduate training supported through several mechanisms including CAP programs to train clinical investigators, supported by the GCRC, have been initiated. The Mallinckrodt GCRC has a long history of excellence in clinical investigation and has been the site of meaningful advances in clinical medicine for more than six decades. It will continue to serve as the major site for inpatient and outpatient clinical investigation at the MGH.