CENTER OF BIOMEDICAL RESEARCH EXCELLENCE IN WOMEN'S HEAL

生物医学研究卓越中心在妇女健康（COBREWH）的目标是加深我们对性别，女性生殖激素和选择性雌激素调节剂（SERMs）在健康和疾病的表现中的独特作用的理解，并将此重点作为一个平台，以发展有前途的初级研究人员，并提高他们在竞争NIH赠款支持的成功。我们将通过以下方式实现这些目标：（1）组建一支由国家卫生研究院资助的科学家组成的骨干队伍，以研究与性别、女性生殖激素和激素作用有关的及时和重要的问题，（2）指导初级教师进行与妇女健康相关的概念方面的最先进的多学科培训，（3）指导初级教师从事以女性健康为重点的研究项目，确保他们成功建立独立的NIH资助的研究职业，（4）开发和支持共享核心设施，以优化COBREWH教职员工在尖端方法中的使用，（5）促进对改善妇女健康至关重要的互补研究领域的试点项目和合作，和（6）战略性地雇用有前途的新教师，以培养一批有资金、有成效和受人尊敬的妇女健康研究人员。COBREWH的一个关键挑战是为初级研究人员提供重点深入的研究经验，提高他们在竞争激烈的资金环境中获得资金的机会，同时提供跨学科的框架，使他们能够长期成长和发展。为了应对这一挑战，我们将COBREWH中的研究分为3个广泛的重叠主题，这些主题将涵盖5个在概念和方法方面相互作用的研究项目。这些研究项目被列入COBREWH，因为它们攻击妇女健康的关键问题，因为肯塔基州大学很幸运，有资深的，资金充足的教师在指导初级调查人员在这些领域的丰富经验。因此，初级研究人员将从NIH资助的教师那里学习，他们利用广泛的最先进的综合，临床，细胞和分子方法来探索妇女健康研究中的关键问题。这种结构将确保拟议的COBREWH计划将满足肯塔基州联邦国家卫生研究院资助的研究呈指数增长的挑战。

The objectives of the Center of Biomedical Research Excellence in Women's Health (COBREWH) are to deepen our understanding of the unique role of gender, female reproductive hormones, and selective estrogen modulators (SERMs) in the manifestation of health and disease and use this focus as a platform to develop promising junior investigators and enhance their success at competing for NIH grant support. We will achieve these objectives by (1) assembling a cadre of established NIH- funded scientists to examine timely and important questions related to gender, female reproductive hormones and hormone action, (2) mentoring junior faculty with state-of-the-art multi-disciplinary training in concepts relevant to women's health, (3) mentoring junior faculty in research projects focused on women's health that will insure that they successfully establish independent NIH-funded research careers, (4) developing and supporting shared core facilities to optimize use by COBREWH faculty in cutting edge methods, (5) facilitating pilot projects and collaborations in complementary research areas that are essential to improving women's health, and (6) strategically hiring promising new faculty to develop a critical mass of funded, productive and well-respected investigators in women's health research. A critical challenge for the COBREWH is to provide junior investigators with focused in-depth research experiences that enhance their chances to obtain funding in a highly competitive funding environment, while providing the inter-disciplinary framework within which they can grow and thrive over the long-term. To meet this challenge we have divided the research in this COBREWH into 3 broad overlapping themes which will umbrella 5 research projects that interact with each other in terms of concepts and methods. These research projects are included in the COBREWH because they attack critical questions in women's health and because the University of Kentucky is fortunate to have senior, well-funded faculty with extensive experience in mentoring junior investigators in each of these areas. Thus, junior investigators will learn from established NIH-funded faculty who utilize a broad spectrum of state-of-the-art integrative, clinical, cellular and molecular approaches to probe critical questions in women's health research. This structure will insure that the proposed COBREWH program will meet the challenge of exponentially increasing the NIH- funded research in the Commonwealth of Kentucky.