THE MOLECULAR AND CELLULAR BASIS OF BRAIN AGING

该培训计划的目标是为有前途的研究生和博士后研究员在衰老神经生物学方面的成功职业做好准备。我们将提供基础广泛的培训，在现代概念的神经生物学的老化，特别强调改变细胞和分子的相互作用，发生在老化的大脑。培训教师的统一重点是我们对理解神经系统在正常和病理条件下随年龄变化的反应机制的兴趣。该培训计划为不同部门的教师提供了正式的框架，他们对大脑衰老的分子和细胞基础有着共同的兴趣，以提供深入的衰老培训。培训学院的重点是相辅相成的：一些人专注于正常衰老过程中大脑中发生的过程，另一些人强调在衰老大脑中占主导地位的神经病理学疾病，还有一些人使用体内和体外系统来模拟衰老大脑。因此，学员将学习教师谁利用广泛的国家的最先进的方法来探索老龄化研究中的关键问题。在上一个授予期间，我们招募有前途的博士前和博士后研究员，提供最先进的培训，并将他们安置在优秀的职位上的记录是杰出的。我们的成功证明了我们有能力识别，吸引，培训和安置有前途的年轻研究人员在老龄化领域是明确的，由于我们不断变化的人口和增加的平均寿命。正常的衰老或神经系统的病变占老年人死亡的很大比例。只有我们更好地了解调节大脑衰老的基本机制，并将其应用于老年人的治疗，我们才有希望改善后半生的生活质量。我们吸引和培养研究生和博士后研究员的能力，以满足在衰老的神经生物学领域的挑战将大大提高这个培训计划。

The goal of this Training Program is to prepare promising graduate students and postdoctoral fellows for successful careers in the neurobiology of aging. We will provide broad-based training in modern concepts in the neurobiology of aging with specific emphasis on changing cellular and molecular interactions that occur in the aging brain. The unifying focus of the training faculty is our interest in understanding the mechanisms by which the nervous system responds to changes that occur with age under normal and pathological conditions. This Training Program provides the formal framework for faculty in different departments, who share a common interest in the molecular and cellular basis of brain aging, to provide in depth training in aging. The emphasis of the Training Faculty complement each other: some focus on processes that occur in the brain during normal aging, others emphasize the neuropathological diseases that predominate in the aging brain, and still others use in vivo and in vitro systems to model the aging brain. Thus, trainees will learn from faculty who utilize a broad spectrum of state-of-the-art methodological approaches to probe critical questions in aging research. During the previous granting period, our record of recruiting promising pre- and post-doctoral fellows, providing state-of- the-art training, and placing them in excellent positions is outstanding. Our success attests to our ability to identify, attract, train and place promising young investigators in the area of aging is clear due to our changing demography and the increasing average lifespan. Normal aging or pathology of the nervous system account for a large percent of deaths in the elderly. Only if we better understand the basic mechanisms that regulate the aging of the brain and apply this to the treatment of the elderly, can we hope to improve the quality of life during the latter half of the lifespan. Our ability to attract and train graduate students and postdoctoral fellows to meet the challenges in the area of neurobiology of aging will be greatly enhanced by this Training Program.