Dissecting the functions of accessory subunits in mitochondrial complex I

线粒体是我们细胞的能量发电站，它产生化学三磷酸腺苷，用于肌肉收缩和触发神经等功能。线粒体复合体I是帮助制造ATP的分子马达。“线粒体疾病”常见于复合体I缺陷导致幼儿死亡。在这个项目中，我们将研究复合体I组分的结构重要性，并研究它们在线粒体中也有额外功能的假设。

Mitochondria are the powerhouses of our cells that produce the chemical ATP for functions such as muscle contraction and triggering of nerves. Mitochondrial Complex I is a molecular motor that helps to make this ATP. “Mitochondrial disease” is often seen when Complex I is defective resulting in early childhood death. In this project we will study the structural importance of components of Complex I and investigate the hypothesis that they also have additional functions in mitochondria.