NEURAL CIRCUITRY AND COGNITIVE FUNCTION IN SCHIZOPHRENIA

虽然精神分裂症的诊断是基于其现象学 症状和纵向过程，几乎所有的精神分裂症患者 表现出严重的认知功能障碍的关系 认知缺陷和神经解剖功能障碍以及 精神分裂症不被理解。最近开发的模型 人类和非人类脑功能与认知的关系 灵长类动物表明，即使是最基本的认知功能， 由复杂的神经回路控制这些模型的出现，加上 神经解剖定位模型无法解释症状 精神分裂症的认知缺陷和症状， 精神分裂症可以解释为神经回路功能障碍， 这些病人。项目1将解决认知之间的关系 精神分裂症的神经解剖激活缺陷和模式， 通过PET评估。项目2将涉及测试神经回路模型 精神分裂症患者功能障碍的验证性路径分析 分析.这些项目将通过实验室的工作， 人类神经组织的连接，特别是神经回路 连接前额叶皮层与丘脑和海马体， 尾状核、内嗅皮层和海马旁回。最终 拟议研究计划的第一阶段将建立在所获得的技能， 职业发展计划的一部分，侧重于基础神经科学， 神经网络建模

Although schizophrenia is diagnosed on the basis of its phenomenological symptoms and longitudinal course, almost all schizophrenic patients demonstrate significant cognitive dysfunction. The relationship between cognitive deficits and the neuroanatomic dysfunction and symptoms of schizophrenia is not understood. Recently developed models of the relationship between brain function and cognition in human and nonhuman primates suggest that even the most basic cognitive functions are mediated by complex neural circuitry. The advent of these models, coupled with the inability of neuroanatomic localization models to account for the symptoms of schizophrenia, suggest that the cognitive deficits and symptoms of schizophrenia may be explained by dysfunctions in the neural circuitry of these patients. Project 1 will address the relationship between cognitive deficits and patterns of neuroanatomic activation in schizophrenia as assessed by PET. Project 2 will involve testing models of neural circuitry dysfunction in schizophrenia by analyzing PET data with confirmatory path analysis. These projects will be informed by laboratory work on the connectivity of human neural tissue, particularly the neural circuits connecting the prefrontal cortex with the thalamus and the hippocampus via the caudate nucleus, entorhinal cortex and parahippocampal gyrus. The final phase of the proposed research plan will build upon the skills acquired as part of the career development plan focusing on basic neuroscience and neural network modeling.