GENERAL CLINICAL RESEARCH CENTER

亚拉巴马大学伯明翰综合临床研究中心 是一个多学科的设施提供给教师的 医学和牙科学院，以追求临床 调查GCRC及其工作人员促进了对 实验条件，密切观察和准确监测， 生物现象，以及生物化学和 发生在患者和正常志愿者中的生理事件 参与研究活动。为了提高效率 以及个人资助项目的研究工作的生产力， 为参与者提供更多的灵活性，以采取新的研究方向， 并促进多个群体之间的合作研究， 科学的学科方法，我们已经谈判了一个 与大学医院的新设施。这将包括住院患者 和门诊设施，以及处理实验室和基因 治疗核心实验室位于九楼的一个独立区域， 医教楼，毗邻西亭住院部。 基因治疗核心将补充UAB基因治疗/疫苗载体 核心以及解决目前和预期的基因治疗需求 未来几年。一个单独的房间套房，将容纳CDMAS 生物统计学家和协调员的设施和办公室将设在 位于GCRC单元正下方的同一建筑物的二楼， 可通过电梯到达。除了上述设施外， 本申请包括对生理学的支持请求， 代谢核心实验室设施，位于现有能源 营养科学系代谢研究组。的 拟议的生理学和代谢核心将提供专业知识 在测量和解释生理和提供访问 在测量和解释以及生理方面的专业知识 并提供获取测量和解释 生理生化参数重要传导基础 GCRC批准的研究者的临床全身代谢研究。 GCRC设施的变化将适应现有的研究活动 以及对基因治疗的新重视。

The University of Alabama at Birmingham General Clinical Research Center is a multi-disciplinary facility available to faculty members of the Schools of Medicine and Dentistry for the pursuit of clinical investigation. The GCRC and its staff facilitate the meticulous control of experimental conditions, close observation and accurate monitoring of biologic phenomena, and the precise measurement of biochemical and physiological events which occur in patients and normal volunteers participating in research activities. In order to increase the efficiency and productivity of research efforts on individually funded projects, afford participants more flexibility in taking new research directions, and promoter more collaborative research among groups having multi- disciplinary approaches to science, we have negotiated construction of a new facility with University Hospital. This will include both inpatient and outpatient facilities as well as a processing laboratory and a Gene Therapy Core Laboratory in a discrete area on the ninth floor of the Medical Education Building, adjacent to the West Pavilion inpatient rooms. The Gene Therapy CORE will complement the UAB Gene Therapy/Vaccine Vector Core as well as address gene therapy needs for the present and anticipated future years. A separated suite of rooms which will house the CDMAS facility and offices for biostatisticians and coordinators will be located on the second floor of the same building directly below the GCRC unit and accessible via an elevator. In addition to the facilities listed above, this application includes a request for support for a Physiology and Metabolism Core Laboratory Facility, housed in the existing Energy Metabolism Research Unit in the Department of Nutrition Sciences. The proposed Physiology and Metabolism Core will provide access to expertise in the measurement and interpretation of physiological and provide access to expertise in the measurement and interpretation and of physiological and provide access to expertise in the measurement and interpretation of physiological and biochemical parameters essential conducting base clinical whole-body metabolic research for GCRC approved investigators. Changes in the GCRC facility will accommodate existing research activities as well as the perceived new emphasis on gene therapy.