LEAD AND ORGANOCHLORINES

这个协作的、多学科的超级基金有害物质 基础研究计划将研究目前的城市来源， 铅的环境分布和对人类健康的毒性影响， 持久性氯化碳氢化合物，特别是多氯联苯和滴滴涕。 研究方案将在纽约市进行。 的 纽约的环境受到严重的铅污染， 有机氯 铅基油漆覆盖了数百座桥梁， 成千上万的公寓，铅是丰富的沉积物中的新 约克港。 多氯联苯污染了从奥尔巴尼北部到 曼哈顿的底部，由于多氯联苯的污染， 下哈德逊是全国最大的超级基金所在地。 具体 本方案的研究将审查： * 哈德逊河和纽约港中铅的当前来源。 * 妊娠期内源性骨铅的动员 来源于城市女性。 * 城市妇女绝经期铅的动员 女性及其与神经心理功能障碍的可能联系。 * 哈德逊河中氯代烃的来源和分布 河和纽约港。 * 纽约港的氯代烃 沉积物显示激素活性。 * 多氯联苯或多氯联苯污染的港口沉积物可能 增强体外正常人乳腺细胞中致癌物的代谢。 这些项目的重点是妇女、儿童、少数民族和 衰老 他们将提供一个科学合理的基础， 减毒和疾病预防。 他们将得到一个 管理核心和支持核心提供统计和数据 管理专业知识、稳定铅同位素分析、痕量金属分析 和化学分析。 该计划还将包含一个社区 外展核心，介绍市中心的高中学生， 环境研究和学生暑期奖学金计划， 大学生的环境研究。

This collaborative, multidisciplinary, Superfund Hazardous Substances Basic Research Program will study the current urban sources, environmental distribution and toxic effects on human health of lead and persistent chlorinated hydrocarbons--in particular PCBs and DDT. The research Program will be undertaken in New York City. The environment of New York is heavily contaminated with lead and organochlorines. Lead-based paint coats hundreds of bridges and thousands of apartments, and lead is abundant in the sediments of New York Harbor. PCBs contaminate the Hudson River from north of Albany to the bottom of Manhattan, and in consequence of its contamination by PCBs, the lower Hudson is the nation's largest Superfund site. Specific studies in this Program will examine: * The current sources of lead in the Hudson River and New York Harbor. * The mobilization of lead during pregnancy from endogenous skeletal sources in urban women. * The mobilization of lead during surgically induced menopause in urban women and its possible association with neuropsychological dysfunction. * The sources and distribution of chlorinated hydrocarbons in the Hudson River and New York Harbor. * The possibility that chlorinated hydrocarbons in New York harbor sediments exhibit hormonal activity. * The possibility that PCBs or PCB-contaminated harbor sediments may enhance carcinogen metabolism in normal human mammary cells in vitro. These Projects focus on women, children, minority populations and the aging. They will provide a scientifically sound basis for exposure attenuation and disease prevention. They will be supported by an administration core and by support cores providing statistical and data management expertise, stable lead isotope analysis, trace metal analysis and chemical analysis. The Program will also contain a community outreach core for introducing inner-city high school students to environmental studies and a student summer fellowship program in environmental research for college undergraduates.