LEAD AND ORGANOCHLORINES

这一合作、多学科、超级基金有害物质 基础研究计划将研究当前的城市污染源， 铅和铅的环境分布及对人体健康的毒性效应 持久性氯代烃--特别是多氯联苯和滴滴涕。 研究计划将在纽约市进行。这个 纽约的环境受到严重的铅污染和 有机氯。铅基涂料覆盖了数百座桥梁和 数以千计的公寓，而在纽约的沉积物中铅丰富 约克港。多氯联苯污染从奥尔巴尼北部到哈德逊河 曼哈顿的底部，由于受到多氯联苯的污染， 哈德逊河下游是美国最大的超级基金网站。特定的 本计划中的研究将检查： *哈德逊河和纽约港目前的铅来源。 *妊娠期间从内源性骨骼中动员铅 在城市妇女中的来源。 *在城市手术诱导的更年期期间铅的动员 女性及其与神经心理功能障碍的可能关联。 *哈德逊河中氯代烃的来源和分布 里弗河和纽约港。 *纽约港中的氯代烃可能 沉积物表现出荷尔蒙活性。 *多氯联苯或受多氯联苯污染的港口沉积物可能 增强体外正常人乳腺细胞的致癌物代谢。 这些项目的重点是妇女、儿童、少数群体和 衰老。它们将为暴露提供科学可靠的基础。 减毒防病。他们将得到一个 管理核心和提供统计和数据的支持核心 管理专长，稳定铅同位素分析，痕量金属分析 和化学分析。该计划还将包含一个社区 将市中心的高中生介绍给 环境研究和学生暑期奖学金计划 面向本科生的环境研究。

This collaborative, multidisciplinary, Superfund Hazardous Substances Basic Research Program will study the current urban sources, environmental distribution and toxic effects on human health of lead and persistent chlorinated hydrocarbons--in particular PCBs and DDT. The research Program will be undertaken in New York City. The environment of New York is heavily contaminated with lead and organochlorines. Lead-based paint coats hundreds of bridges and thousands of apartments, and lead is abundant in the sediments of New York Harbor. PCBs contaminate the Hudson River from north of Albany to the bottom of Manhattan, and in consequence of its contamination by PCBs, the lower Hudson is the nation's largest Superfund site. Specific studies in this Program will examine: * The current sources of lead in the Hudson River and New York Harbor. * The mobilization of lead during pregnancy from endogenous skeletal sources in urban women. * The mobilization of lead during surgically induced menopause in urban women and its possible association with neuropsychological dysfunction. * The sources and distribution of chlorinated hydrocarbons in the Hudson River and New York Harbor. * The possibility that chlorinated hydrocarbons in New York harbor sediments exhibit hormonal activity. * The possibility that PCBs or PCB-contaminated harbor sediments may enhance carcinogen metabolism in normal human mammary cells in vitro. These Projects focus on women, children, minority populations and the aging. They will provide a scientifically sound basis for exposure attenuation and disease prevention. They will be supported by an administration core and by support cores providing statistical and data management expertise, stable lead isotope analysis, trace metal analysis and chemical analysis. The Program will also contain a community outreach core for introducing inner-city high school students to environmental studies and a student summer fellowship program in environmental research for college undergraduates.