ALCOHOL, INFECTION, AND HOST RESPONSE

酒精研究中心的这项题为“酒精感染和 宿主反应”，是一组活跃的， 独立的，原创的科学家，联合收割机他们的智力和 建立一个区域酒精中心， 他们的科学效率和生产力，并将作为一个区域 酒精相关研究、教育和 信息传递 拟建中心的研究工作将 加强和扩大目前对酒精的调查， 路易斯安那州立大学医学中心的相关研究， 更加跨学科。 参与的高级研究员是 提出了三个重大科学项目，题目是：（1） “酒精与宿主防御相关的肝功能”，（2）“酒精， 免疫抑制和宿主防御”，和（3）“酒精诱导的调节 细胞因子和一氧化氮在大鼠肺中的作用”。 三个核心单位是 建议：a）行政核心; B）动物核心设施处理 随着手术准备，以及喂养和处理的 慢性酒精动物;和c）具有组织培养物的实验室核心 和分析组件。 核心单位也将有一个主要的 对目前资助的NIAAA支持的研究产生有益影响 几位调查员的工作。 此外，四个试点项目 提案中包含了一些内容，以及其他几个内容的简要概述 未来可能的试点项目。 后一组包括一项建议， 这将最终导致临床研究利用现有的 综合临床研究中心，以及研究和培训 泽维尔大学的教师和学生的机会， 黑人占主导地位的机构。 最后，一个强大的研究组成部分 培训和信息传递也是 建议ARC。 这一急需的区域中心将大大有助于 我们对代谢和免疫损伤的理解， 酗酒对我们的人口造成的后续损害。

This Alcohol Research Center proposal, entitled "Alcohol Infection and Host Response", is a coordinated effort on the part of a group of active, independent, original scientists to combine their intellectual and physical resources to create a regional alcohol center that will improve their scientific efficiency and productivity and will serve as a regional resources in the field of alcohol-related research, education and information transfer. The research efforts of the proposed Center will re-enforce and expand the currently existing investigations of alcohol- related research at Louisiana State University Medical Center and make them more interdisciplinary. The participating senior investigators are proposing three major scientific projects that are entitled: (1) "Alcohol ad host defense related hepatic function", (2) "Alcohol, immunosuppression and host defense", and (3) "Alcohol-induced modulation of cytokines and nitric oxide in rat lung". Three Core Units are proposed: a) an Administrative Core; b) an Animal Core facility dealing with the surgical preparation, as well as the feeding and handling of the chronic alcoholic animals; and c) a Laboratory Core with tissue culture and analytical components. The Core Units will also have a major beneficial impact on the presently funded NIAAA-supported research activities of several investigators. In addition, four Pilot Projects are included in the proposal, as well as brief outlines of several other potential future Pilot Projects. The latter group includes a proposal that will eventually result in clinical studies utilizing the available General Clinical Research Center, and also research and training opportunities for faculty and students of Xavier University, a predominantly black institution. Finally a strong component of research training and information transfer is also an integral part of the proposed ARC. This much-needed regional center will greatly contribute to our understanding of the metabolic and immunologic impairments and subsequent damage that alcohol abuse inflicts upon our population.