ANALYSIS DEVELOPMENT COMPONENT

一项旨在对整个人类基因组进行测序的资助计划正在进行中。 通过计算工具鉴定功能性序列元件， 变得越来越重要。我们的长期目标是使用数学 和统计方法来识别最重要的功能元素-- 蛋白质编码基因及其调控元件来自一个大的基因组 序列的最近，我们开发了一种新的人类外显子查找器，称为MZEF (PNAS 94：565-568，1997），基于现代多元统计分析， 模式识别技术在人类18号染色体上 测序项目，我们计划改善和扩大我们的MZEF在一个真实的 大规模序列生产设置和整合新方法 （特别是第一个和最后一个外显子预测方法）将在 张博士实验室的其他资助研究项目。我们将 与信息核心和其他组件紧密交互， 来测试准确性、效率和可扩展性。发展计算 帮助侏儒快速注释的方法也至关重要， 实现人类基因组计划的目标，这反过来又将有一个 对人类健康和医学产生深远影响。

A grant effort is underway to sequence the entire human genome. Identification of functional sequence elements by computational tools has become increasingly important. Our long time goal is to use mathematical and statistical methods to identify most important functional elements-- protein coding genes and their regulatory elements from a large genomic sequences. Recently, we have developed a new human exon-finder called MZEF (PNAS 94:565-568, 1997), based on a modern multivariate statistical pattern recognition technique. In the proposed human chromosome 18 sequencing project, we plan to improve and to extend our MZEF in a real large-scale sequence production setting and to integrate new methods (especially first and last exon prediction methods) to be developed under the other funded research projects in Dr. Zhang's Laboratory. We shall interact with the informatics-core and other components closedly in order to test for accuracy, efficiency and scalability. Developing computational methods to assist rapid annotation of the gnome will also be vital for achieving the goals of Human Genome Project, which in turn will have a profound impact on human health and medicine.