SCOR--MOLECULAR GENETICS OF HYPERTENSION

申请书建议建立一个专门的研究中心 （SCOR）在爱荷华州大学的高血压分子遗传学中的应用 心血管中心。 我们一直在计划的这一举措 18个月，汇集了一批新的调查人员，包括 杰出的分子遗传学家（爱荷华州的瓦尔谢菲尔德和柯特西格蒙德 和俄亥俄州的John Rapp）;遗传流行病学家和生物统计学家 （Trudy Burns）;和高血压生理学家（Gerald DiBona，John Stokes， 加里鲍姆巴赫、让·罗比拉德、大卫梅里尔和阿林·马克） 高血压分子遗传学SCOR计划的三大目标。 该提案的优点包括： 1)研究三个不同的人群，包括核心家庭 来自马斯卡廷人口肥胖和血压研究;贝都因人 来自以色列南部同质人口的家庭， 肥胖和高血压的发病率;以及全州范围的妇女网络 先兆子痫; 2)由瓦尔领导的人类分子遗传学核心实验室 具有高通量基因分型能力的谢菲尔德， 全基因组搜索; 3)协调追求染色体数量性状基因座， 生理和细胞中间表型的大鼠模型中， 遗传性盐敏感性高血压;以及 4)组织特异性基因表达和敲除在转基因中的应用 小鼠来测试组织特异性肾素-血管紧张素系统在 高血压 我们SCOR的调查人员，包括俄亥俄州的约翰·拉普， 建立了积极的合作和密切的互动。此外，本发明还提供了一种方法， 我们SCOR的调查人员还建立了广泛的 与其他高血压遗传学研究人员的合作。 这个领先的分子遗传学家和高血压的联盟 爱荷华州SCOR的生理学家们承诺， 对提高人类遗传学分子水平的贡献 高血压

The application proposes to establish a Specialized Center of Research (SCOR) in the Molecular Genetics of Hypertension in the University of Iowa Cardiovascular Center. This initiative, which we have been planning for 18 months, brings together a new cadre of investigators including outstanding molecular geneticists (Val Sheffield and Curt Sigmund at Iowa and John Rapp in Ohio); a genetic epidemiologist and biostatistician (Trudy Burns); and hypertension physiologists (Gerald DiBona, John Stokes, Gary Baumbach, Jean Robillard, David Merrill and Allyn Mark) to pursue the three broad goals of the Hypertension Molecular Genetics SCOR program. The strengths of the proposal include: 1) study of three distinctive human populations including nuclear families from the Muscatine population study of obesity and blood pressure; Bedouin families from a homogeneous population in Southern Israel with a high incidence of obesity and hypertension; and a statewide network of women with preeclampsia; 2) a lcading core human molecular genetics laboratory directed by Val Sheffield with capability for high throughput genotyping facilitating genome wide searches; 3) coordinated pursuit of chromosomal quantitative trait loci and physiologic and cellular intermediate phenotypes in rat models of genetically salt-sensitive hypertension; and 4) the use of tissue specific gene expression and knockouts in transgenic mice to test the role of tissue-specific renin-angiotensin systems in hypertension. The investigators in our SCOR, including John Rapp in Ohio, have established active collaborations and intense interaction. In addition, the investigators in our SCOR have also established extensive collaborations with other investigators in the genetics of hypertension. This coalition of leading molecular geneticists and hypertension physiologists in the Iowa SCOR holds promise for a substantial contribution to advancing knowledge of the molecular genetics of hypertension.