CASE CONTROL ETIOLOGIC STUDY OF SARCOIDOSIS

美国的10个临床中心正在招募病例， 美国国立卫生研究院赞助的一项名为“一项病例对照病因学研究， 结节病“目标包括：1）检验关于 环境、职业、生活方式和其他危险因素 结节病，2）检查结节病的家族聚集性，3） 测试关于结节病聚集的遗传假设，4）为了 描述结节病的自然史，特别是在群体中 比如非洲裔美国人，他们似乎受到了不成比例的影响， 5)确定进展为更严重疾病的风险因素， 6（实施一种用于存储生物样本的系统，包括 来自病例和对照受试者的血细胞、血浆和血清，以及 支气管肺泡灌洗液和细胞来自一个充分表征的系列 结节病的病例代表了从轻度到重度的范围， 疾病

Ten clinical centers in the United States are recruiting cases for an NIH sponsored study titled "A Case Control Etiologic Study of Sarcoidosis." The objectives include: 1) to test hypotheses concerning environmental, occupational, lifestyle, and other risk factors for sarcoidosis, 2) examine the familial aggregation of sarcoidosis, 3) To test genetic hypotheses concerning aggregation of sarcoidosis, 4) To describe the natural history of sarcoidosis, particularly among groups such as African-Americans who appear to be disproportionately affected, 5) To identify risk factors for progression to more sever disease and 6( To implement a system for storing biological specimens including blood cells, plasma, and serum from cases and control subjects and bronchoalveolar lavage fluid and cells from a well characterized series of cases of sarcoidosis which represent the spectrum from mild to severe disease.