CHRONIC BERYLLIUM DISEASE AMONG BERYLLIUM EXPOSED WORKERS

铍的职业空气标准的起源是基于 其他重金属如砷、铅和汞的毒性和 经过修改以反映铍的较低原子量和对 它的毒性更大。没有关于健康结果的流行病学研究 暴露于空气中是为了在最初推荐的空气中达成共识 2微克/立方米的标准。近50年后，这仍然是目前的空气 OHSA和能源部在工作场所执行的水平。最新研究 看着铍的疾病和暴露使用了替代的 并发现随着接触的增加，疾病也随之增加。在……里面 此外，宿主因素的贡献已经在一个 一成不变的时尚，而不同时检查暴露水平。 慢性铍病现在可以用增殖来诊断。 肺灌洗液或外周血中的淋巴细胞检测。 然而，后续研究以表征其临床意义。 需要扩散试验的阳性结果。这个项目 将调查各种可能的暴露-反应关系 暴露的测量，包括化学和物理形式的铍 致敏与临床疾病。将在中检查主机因素 结合暴露数据，更好地解决宿主问题 敏感度。最后，铍病的自然历史在 增殖试验呈阳性的个人将被确定。

The origin of the occupational air standard for beryllium was based on the toxicity of other heavy metals such as arsenic, lead and mercury and modified to reflect beryllium's lower atomic weight and concern about its greater toxicity. No epidemiological studies of health outcomes and exposure were used to reach a consensus on the initial recommended air standard of 2ug/m3. Almost 50 years later this remains the current air level that OHSA and DOE enforce in the work place. Most recent studies looking at beryllium disease and exposure have used surrogates of exposure and found increased disease with increased exposure. In addition, the contributions of host factors have been examined in an unvariate fashion without simultaneously examining exposure levels. Chronic beryllium disease can now be diagnosed using proliferation lymphocyte tests from either the lung lavage fluid or peripheral blood. However, follow-up studies to characterize the clinical significance of positive findings of the proliferation tests are needed. This project will investigate possible exposure-response relationships for various measures of exposure, including chemical and physical form, beryllium sensitization and clinical disease. Host factors will be examined in conjunction with exposure data to better address the issue of host susceptibility. Finally, the natural history of beryllium disease in individuals with positive proliferation tests will be determined.