DIETARY MANIPULATION IN UREMIA--ACIDOTIC PATIENTS

本方案是#327的修改，用于研究代谢性酸中毒， 透析病人修改后的方案将提高患者 招聘它还将允许调查人员确定是否 代谢性酸中毒刺激血液透析患者的蛋白质代谢 以及这是否至少部分是由于基因的激活 负责骨骼肌中的蛋白质和氨基酸降解。的 修订后的方案已获得IRB和GCRC批准，招募已 开始.

This protocol is a modification of #327 to study metabolic acidosis in dialysis patients. The modified protocol will enhance patient recruitment. It will also allow the investigators to determine whether metabolic acidosis stimulates protein catabolism in hemodialysis patients and whether this is due, at least, in part to activation of genes responsible for protein and amino acid degradation in skeletal muscle. The revised protocol has received IRB and GCRC approval, and recruitment has begun.