SERUM AND URINE GONADOTROPINS IN SEX STEROIDS IN NORMALLY CYCLING WOMEN

作为试点可行性研究，为大型多中心做准备 全国妇女研究（SWAN），本议定书将记录 卵泡血清促性腺激素水平的相关性 促性腺激素（FSH）、促黄体生成激素（LH）和性腺激素 类固醇雌二醇和孕酮与尿FSH、LH和 甾体代谢物培格南汀葡糖苷酸和雌酮 葡糖苷酸。将在7个临床研究中心共招募35名女性 进行可行性研究。预计良好的相关性 尿液和血清水平之间的差异将在准备 较大母方案中计划的泌尿系统研究。

As a pilot feasibility study in preparation for the large multi-center Study of Women Across the Nation (SWAN), this protocol will document the correlation between serum levels of the gonadotropins follicle stimulating hormone (FSH) and lutinizing hormone (LH) and the gonadal steroids estradiol and progesterone with urinary levels of FSH, LH and the steroid metabolites pergnanediol glucuronide and estrone glucuronide. A total of 35 women will be recruited at 7 clinical sites for this feasibility study. It is anticipated that good correlation between urinary and serum levels will be noted in preparation for the planned urinary studies in the larger parent protocol.