EARLY ADMINISTRATION OF BECLOMETHASONE IN PREMATURE NEONATES AT RISK FOR BPD

摘要支气管肺发育不良(BPD)是一种常见的肺部并发症。 早产儿。治疗呼吸机依赖的主要目标 早产儿是为了最大限度地减少慢性肺损伤所致 每桶。因此，呼吸机支持和氧气补充必须 迅速减少。研究表明，静脉注射 地塞米松加速了这一结果。然而，皮质类固醇类药物最多 通常只有在有意义的肺部发育后才开始 损坏，即。在出生后两到四周之间。我们将评估 吸入倍氯米松后5天内起效 对生命、肺功能、肺部炎症和持续时间的影响 机械通气治疗早产儿严重呼吸窘迫 窘迫综合症。这是第一项评估效率和 吸入类固醇的不良反应在病理性早期就开始了 和炎症过程。

Bronchopulmonary dysplasia (BPD) is a common pulmonary complication of prematurity. A primary objective in treating ventilator-dependent premature infants is to minimize chronic lung damamge associated with BPD. Ventilaator support and oxygen supplementation must therefore be reduced expeditiously. Studies have demonstrated that intravenous dexamethasone hastens this outcome. However, corticosteroids ae most commonly initiated only after the development of significant lung damage, ie. between two and four weeks after birth. We will assess the effect of inhaled beclomethasone, inititated within the first 5 days of life, on pulmonary function, pulmonary inflammation, and duration of mechanical ventilation in premature neonates with severe respiratory distress syndrome. This is the first study to assess the efficiacy and adverse effects of inhaled steroids initiated early in the pathologic and inflammatory process.