ALPRAZOLAM INDUCED CHANGES IN CEREBRAL BLOOD VOLUME

目的：比较不同的药物刺激对患者的主观感受， 阿普唑仑与客观标志物，局部脑血变化 通过快速磁共振成像（fMRI）测量的rCBV，以及 检验了右额叶rCBV降低 而右尾状核与欣快的程度呈负相关 受试者。 方法：这是一项双盲、安慰剂对照方案， 比较18-24岁酗酒者的成年子女的反应， （ACOAs）和正常对照之间的相互关系。 结果：7例ACOAs患者左额叶rCBV改变与ACOAs的发生、发展及预后有关， 与药物反应的大小成反比（r=-0.89，p <0.007）。 结论：fMRI可用于检测脑功能中的chugs， 与受试者的主观体验相关。

Objective: This study compares the subjective feelings induced by aprazolam with an objective marker, changes in regional cerebral blood volume (rCBV) as measured by fast Magnetic Resonance Imaging (fMRI) and tests the hypothesis that the decrease in rCBV in the right frontal lobe and right caudate is inversely related to the degree of euphoria reported by the subjects. Method: This is a double blind, placebo controlled protocol which will compare the response of 18-24 year old adult children of alcoholics (ACOAs) and normal controls to themselves and to each other. Results: In our study of 7 ACOAs the left frontal rCBV change correlated inversely with the magnitude of the drug response (r=-0.89, p<0.007). Conclusion: fMRI can be used to detect chugs in brain function which correlate with the subjective experiences of the subjects.