MECHANISM OF INCR PLASMA APO A1 LEVELS BY ESTROGENS

绝经后妇女患冠心病的风险更高 甚至在控制了年龄效应之后。 然而，雌激素替代疗法显著降低冠心病的风险 在绝经后妇女中。 通过这项研究，我们建议确定 载脂蛋白A-I的动力学，高脂血症的主要蛋白组分， 密度脂蛋白，在绝经后妇女接受安慰剂- 使用以下每种方案进行对照、随机化治疗： a.安慰剂; B.结合雌激素0.625mg/d; C.结合雌激素0.625mg/d+醋酸甲羟孕酮2.5mg/d。 将通过稳定同位素技术测定载脂蛋白A-I的动力学。 低剂量雌激素（B）和雌激素-孕酮组合（c）是 经常处方ro绝经后妇女作为激素替代 治疗，但没有研究比较这两个效果 治疗对血浆脂质代谢和载脂蛋白动力学的影响。

Postmenopausal women are at higher risk of coronary heart disease (CHD) than premenopausal women, even after controlling for age-effects. However, estrogen replacement therapy significantly lowers the risk of CHD in postmenopausal women. With the study, we propose to determine the kinetics of apolipoprotein A-I, the major protein component of high density lipoproteins, in postmenopausal women undergoing a placebo- controlled, randomized treatment with each of the following regimens: a. placebo; b. 0.625mg/d conjugated estrogens; c. 0.625mg/d conjugated estrogens + 2.5 mg/d medroxyprogesterone acetate. The kinetics of apo A-I will be determined by stable isotope techniques. The low dose estrogen (b) and the estrogen-progestin combination (c) are frequently prescribed ro postmenopausal women as hormone replacement therapy, but there are no studies comparing the effects of these two treatments on plasma lipid metabolism and apolipoprotein kinetics.