Dnmt3L haploinsufficent retrotransposition leads to genetic hypermutation

该项目旨在证明DNA甲基化作为突变的原因以及遗传疾病，许多不育和低生育率以及癌症的重要性。由于DNA甲基化可以部分地由底物的可用性决定，因此DNA甲基化维斯维斯突变率的重要性的证明将完善我们对代谢和营养对突变率的影响作为人类疾病原因的理解。

This project aims to demonstrate the critical importance of DNA methylation as a cause of mutation and thus genetic diseases, many instances of sterility and low fertility, and cancers. Because DNA methylation can be partially determined by substrate availability, a demonstration of the importance of DNA methylation vis a vis mutation rates will refine our understanding of the impact of metabolism and nutrition on mutation rate as a cause of human disease.