METABOLISM OF NON ESSENTIAL AMINO ACIDS IN HUMAN PREGNANCY

拟议的研究将量化丝氨酸的动力学和新陈代谢。 并检测其与胎儿生长的可能关系 通过检查这些患有巨大儿和宫内的人群 发育迟缓。据推测，随着怀孕的进展和 随着尿素合成速度的下降， 肝内氮代谢发生在以下情况下 来自尿素前体的氮被转移到合成非 必需的氨基酸，如丝氨酸和甘氨酸，葡萄糖是 丝氨酸碳的主要来源。进一步假设 大量的丝氨酸和甘氨酸可能被转移到 胎儿。 妊娠期糖尿病的特征是蛋白质分解增加， 因此，预计丝氨酸和丝氨酸的比率会增加 甘氨酸周转率。调查计划仍在继续研究中 正常孕妇，胰岛素依赖型糖尿病孕妇， IUGR胎儿的孕妇，接受定期剖腹产的妇女 剖腹产和非妊娠对照。正常的孕妇会是 在怀孕期间连续学习。

The proposed studies will quantify the kinetics and metabolism of serine during human pregnancy and examine its possible relation to fetal growth by examining such populations with fetal macrosomia and intrauterine growth retardation. It is hypothesized that as gestation advances and as the rates of urea synthesis decline, a significant change in the intrahepatic nitrogen metabolism occurs wherein increased amounts of nitrogen from ureagenic precursors are transferred to synthesize non- essential amino acids such as serine and glycine, and that glucose is a major source of serine carbon. It is further hypothesized that significant amounts of serine and glycine may be transferred to the fetus. Diabetes in pregnancy is characterized by increased protein breakdown, and thus it is expected that there is an increased rate of serine and glycine turnover. The plan of investigation continues to be to study normal pregnant women, pregnant women with insulin dependent diabetes, pregnant women with IUGR fetuses, women undergoing scheduled cesarean sections and non-pregnant controls. The normal pregnant women will be studied serially through pregnancy.