Surface coated nanodiamonds as drug delivery carriers and simultaneous imaging

设计和开发下一代纳米载体作为药物递送平台是化学和材料科学领域的一个持续挑战。纳米金刚石由于其生物相容性、易于功能化和非漂白荧光而成为有吸引力的候选物。该项目提出了一种创新的方法，将各种聚合物链接枝到纳米金刚石表面，以产生聚合物-无机杂化材料。该项目将扩大我们对聚合物链对纳米金刚石稳定性和细胞摄取的影响的了解。模型药物吉西他滨和靶向生物活性配体也将缀合到用于药物递送研究的最佳制备的杂化材料上。

The design and development of next-generation nanocarriers as drug delivery platforms is an ongoing challenge in chemical and material sciences. Nanodiamonds are attractive candidates due to their biocompatibility, ease of functionalisation, and non-bleaching fluorescence. This project proposes an innovative approach to graft various polymer chains onto the surface of nanodiamonds to produce polymer-inorganic hybrid materials. This project will expand our knowledge of the influence of polymer chains on the stability of nanodiamonds and cellular uptake. The model drug gemcitabine and targeting bioactive ligands will also be conjugated onto the optimum produced hybrid materials for the drug delivery study.