HUMAN METHIONINE AND HOMOCYSTEINE METABOLISM

这个项目的主要目标是量化转甲基化的速率， 再甲基化、转硫作用和半胱氨酸转换， 没有维生素B6、B12或叶酸缺乏证据的女性， 以亚甲基四氢叶酸还原酶基因突变为特征 和胱硫醚合酶，其次，确定是否 蛋氨酸代谢存在明显的性别差异 据报道，绝经前妇女的同型半胱氨酸水平较低， 妇女在本报告所述期间，对五个主题进行了研究。 所有 很好地接受了研究。 计划：继续招募志愿者。

The major goals of this project are to quantify rates of transmethylation, remethylation, transsulfuration, and cysteine turnover in healthy men and women without evidence of vitamin B6, B12 or folate deficiency and characterized for genetic mutations in methylenetetrahydrofolate reductase and cystathionine-synthase, and secondly, to determine whether or not apparent gender differences in methionine metabolism do exist thereby accounting for the reportedly lower homocysteine levels in premenopausal women. Five subjects were studied during the reporting period. All tolerated the studies well. Plan: To continue recruitment of volunteers.