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SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER

SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER
双相情感障碍多巴胺功能的 SPECT 成像
批准号：
6277291
负责人：
Amit Anand
金额：
$2.8万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6277291
关键词：
amphetamines bipolar depression clinical research dopamine dopamine receptor human subject iodine lithium neurochemistry neurotransmitter transport radiotracer single photon emission computed tomography synapses

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中文摘要
翻译
苯丙胺(AMPH)诱导双相多巴胺(DA)释放的研究 障碍将探索突触前多巴胺释放的异常 机制以及对突触后DA受体的研究。总体目标 这项研究的目的是评估AMPH潜在的神经化学相关性。 双相情感障碍患者目前情绪稳定的挑战 稳定剂，锂。双相情感障碍患者与健康人 年龄、性别和种族血统匹配的对照将接受一次SPECT 用D2示踪剂[123I]IBZM进行试验。
英文摘要
The study of amphetamine (AMPH) induced dopamine (DA) release in bipolar disorder will explore abnormalities in presynaptic dopamine release mechanisms as well as study post-synaptic DA receptors.The general aim of this study is to evaluate potential neurochemical correlates of AMPH challenge in patients with bipolar disorder currently stable on the mood stabilizer--lithium. Patients with bipolar disorder and healthy controls matched for age, sex and ethnic origin will undergo one SPECT experiment with the D2 tracer [123I]IBZM.
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