ALLOPURINOL AND THE PREVENTION OF DEATH, TISSUE INJURY, AND SEIZURES IN CHD

这是一种随机、双盲的治疗方法 别嘌醇对染毒鼠发育脑的神经保护作用 缺氧-缺氧性侮辱。接受心脏手术的婴儿 需要循环骤停的患者使用别嘌醇或 手术前服用安慰剂。主要结果衡量标准是尖锐的。 脑病(包括昏迷和癫痫)和死亡。婴儿经历了 随访中的神经学检查和发育评估 年龄不超过两岁。已知缺氧缺血是一种 细胞死亡和组织坏死的有力原因。其确切的生物化学 受伤情况仍在紧张调查中。其中最令人着迷的 在这一系列研究中的发现是异常的氧代谢 在组织损伤中起作用。有越来越多的证据表明 已经确定氧自由基的形成是一种重要的生化 在最终产生细胞侮辱的情况下运作级联。这 模型提供了一种潜在的干预治疗机制 可能预防或改善缺氧再灌流的后果 受伤。别嘌醇可以防止牙髓中自由基的形成 缺血组织。研究科目的报名工作已于9月完成 1997年5月15日。共有350名患者入选。

This is a randomized, double-blind treatment of the putative neuroprotective effects of Allopurinol on the developing brain exposed to hypoxic-ischemic insults. Infants undergoing cardiac surgery which requires circulatory arrest are treated with either Allopurinol or a placebo prior to surgery. The major outcome measures are acute encephalopathy (including coma and seizures), and death. Infants undergo neurological examination and developmental assessment in follow-up visits up to two years of age. It has been known that hypoxic-ischemia is a potent casue of cell death and tissue necrosis. The exact biochemistry of injury is still under intense investigation. One of the most fascinating discoveries in this line of research is that aberrant oxygen metabolism plays a role in tissue injury. There is a growing body of evidence which has identified oxygen free radical formation as an important biochemical cascade operative in the ultimate production of cellular insult. This model serves to provide a potential therapuetic mechanism of intervention that might prevent or ameliorate the consequences of hypoxia reperfusion injury. Allopurinol may prevent the formation of free radicals in post ischemic tissues. Enrollment of study subjects was completed on September 15, 1997. A total of 350 patients were enrolled.