TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS WITH ORAL BOVINE TYPE II COLLAGEN

我们建议研究口服II型 活动性JRA儿童的胶原蛋白。这将是第一阶段， II期，研究将排除服用DMARD的儿童。我们建议 包括一个安慰剂组，并对研究设盲， 观察将是最小的偏差。 将收集实验室数据， 检查安全性、对炎症活动和自身免疫的总体影响 II型胶原蛋白。

We propose to investigate the effects of oral administration of type II collagen in children with active JRA. This will be a Phase I, and limited Phase II, study which will exclude children taking DMARDs. We propose to include a placebo group and blind the study so that any clinical observation will be minimally bias. Laboratory data will collected to examine safety, overall effect on inflammatory activity, and autoimmunity to type II collagen.