CONTROLLED TRANSFER MODEL FOR AUTOIMMUNE DIABETES

研究计划包括以下内容：1）识别 以及从该细胞中获得的新的β-细胞抗原的分子克隆。 猕猴，随后确定组织分布， 测量对这些抗原的人免疫应答; 2） 影响β细胞的胰岛因子的表征 1型糖尿病的自身抗原表达水平; 3） 用于抗原的β-细胞转染的非人灵长类动物模型 过表达和β细胞永生化。

The research plan consists of the following: 1) Identification and molecular cloning of novel beta-cell antigens obtained from the macaque, subsequent determination of tissue distribution and measurement of the human immune response to these antigens; 2) Characterization of the islet factors that influence beta-cell autoantigen expession levels in Type 1 Diabetes; 3) Development of a non-human primate model of beta-cell transfection for antigen overexpression and beta-cell immortalization.