PET MARKER FOR HIPPOCAMPAL IMAGE: DEXAMETHASONE

摘要目的：建立一种新的猴脑成像技术。 使用最近发现的一种正电子发射断层扫描技术 化学标记。结果为了确定纵向后遗症 地塞米松对小鼠海马神经元的损伤作用 胎儿期，我们对海马体进行了体积测量 年龄匹配的对照组和对照组的MRI图像分割 地塞米松治疗的幼猴。治疗组显示 海马体的体积一直低于对照组猴子。至 检查海马神经元的功能方面，我们已经尝试过 通过PET图像分析[F-18]脱氧葡萄糖的摄取，但 这个标记获得的图像不够具体，无法描绘出来 海马区。阳性区域总体上无处不在。 皮质和基底核。最近，5-HT1a的一种拮抗剂 受体Way-100635被发现是人类 用正电子发射计算机断层扫描(PET)观察猕猴的海马回。在我们的初步数据中， [羰基-11]Way-100635显示出更好的地区性特征 在我们的对照猴子中，海马体的图像比[F-18]化合物。 未来方向使用这个标记器，我们计划进行PET 4例地塞米松治疗组和3例对照组的海马区分析 幼年到成年早期的猴子。KEYWARDS PET图像，5-HT 1A 受体，海马体，地塞米松，恒河猴

OBJECTIVE: To develop a new imaging technique of monkey hippocampus by positron emission tomography using recently found a chemical marker. RESULTS In order to determine longitudial sequela of the hippocampal damages which induced by dexamethasone during their fetal stage, we have used volumetric measurement of the hippocampal segments by MRI images in age-matched control and dexamethasone-treated juvenile monkeys. The treated groups showed consistently lower volume of the hippocampus than control monkeys. To examine the functional aspects of hippocampal neurons, we have tried to analyze the uptake of [ F-18] deoxy-glucose by PET images, but the images obtained by this marker were not specific enough to delineate the hippocampal region. The positive regions were ubiquitous in whole cortical and basal nuclei. Recently, an antagonist of 5-HT 1A receptor, WAY-100635, was found to be a specific marker for the human and macaque hippocampal gyri by PET. In our preliminary data, [Carbonyl-11] WAY-100635 showed much better and regionally specifc PET images of the hippocampus than [F-18] compound in our control monkeys. FUTURE DIRECTIONS Using this marker, we are planning to perform PET analysis of the hippocampus in 4 dexamethasone-treated and 3 control juvenile to early adult monkeys. KEYWARDS PET image, 5-HT 1A receptor, hippocampus, dexamethasone, rhesus monkey