SACCADIC EYE MOVEMENT STUDIES

我们工作的最终目标是了解大脑是如何 功能。我们专注于大脑的输出，或运动部分 功能，以动眼系统为模型。我们最近的研究 扫视眼球运动(快速、阶梯式扫描眼球运动 我们用来“看”我们的视觉世界)揭示了关于 眼跳是如何由神经眼跳发生器编程的。 具体地说，我们发现舌下前置核(NPH) 而Cajal间质核不能提供内部 指定正确扫视的控制信号(本地反馈) 尺码。神经积分器是一个假想的核，它将 将速度编码命令转换成眼睛位置放电，从而 在数学意义上对信号进行积分。我们还展示了 NPH(假定的神经整合者)产生动眼神经 命令信号在古怪的眼睛位置产生稳定的凝视，但 不能用于提供眼位或眼速反馈给 控制扫视轨迹。因此，当前的模型必须修改为 解释了我们最近的结果。这些研究是 眼球运动障碍对神经病学的鉴别诊断 以及我们对动眼神经过程的理解。 此外，它们还为更复杂的研究提供了一个平台 中枢神经系统功能的各个方面，如相互作用 在运动系统之间(例如，定位时的眼睛和头部)或 感觉和运动系统(例如，视觉和眼球运动系统) 以及更抽象的功能，如注意力和记忆力。

The ultimate goal of our work is to understand how the brain functions. We concentrate on the output, or motor portions of brain function, using the oculomotor system as a model. Our recent studies of saccadic eye movements (the quick, step-like scanning eye movements we use to "look at" our visual world) have revealed new details about how saccades are programmed by the neural saccade generator. Specifically, we showed that the nucleus prepositus hypoglossi (nph) and the interstitial nucleus of Cajal cannot provide an internal control signal (local feedback) that specifies the correct saccade size. The neural integrator is an hypothesized nucleus that converts velocity-coded commands into eye-position discharge and thus integrates the signals in a mathematical sense. We also showed that the nph (the putative neural integrator) produces the oculomotor command signals to produce steady gaze at eccentric eye positions but cannot be used to supply eye-position or eye-velocity feedback to control saccade trajectory. Thus, current models must be revised to account for our recent results. These studies are basic to the differential neurological diagnosis based on eye-movement deficits now commonly used as well as to our understanding of oculomotor processes. In addition, they serve as a platform for studies of more complex aspects of central nervous system function, such as the interaction between motor systems (e.g., eye and head during orientation) or sensory and motor systems (e.g., the visual and oculomotor systems) as well as more abstract functions such as attention and memory.