MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER

多功能型关节炎和肌肉骨骼疾病中心 北卡罗来纳大学礼拜堂分校 作为瑟斯顿关节炎研究中心的医学中心，由 生物医学研究部分，教育、流行病学和健康 服务研究(E/E/HSR)组成部分，一个生物分子核心，一个数字 科学核心和一个行政单位。正在进行和计划中的 生物医学研究部分的调查包括许多 与自身免疫、关节炎和肌肉骨骼疾病相关的问题： 正常人和正常人识别元件的遗传学、调节和功能 异常免疫反应；肽/MHC结构功能关系； 细胞因子和炎症反应基因的诱导和调节； T细胞受体和B细胞免疫球蛋白基因谱系及其在人类免疫缺陷中的作用 自身免疫；T细胞激活和信号转导；分子 自身抗体形成的遗传学；自身抗体对 疾病发病机制；免疫抑制；自身免疫激动剂； 实验性关节炎的炎症及其治疗；生化和 软骨细胞生物学；机械关节损伤的病理生理学； 它与骨性关节炎的关系；关节炎的临床研究， 骨质疏松症和全身性结缔组织疾病； 疼痛。提出了三个开发可行性项目。“机制” 抗nRNP/Sm自身抗体的传播 “细胞凋亡”和“饮食甘氨酸预防关节炎”。 生物分子核心提供：血清学和临床数据库和一个细胞 BANK；流式细胞术；近交系小鼠群体；以及生物分子成像 设施。E/E/HSR部分的研究主题包括：1)研究 旨在增加我们对人们如何适应和应对的理解 关节炎；2)制定或验证相关的测量程序 到关节炎；3)流行病学研究，旨在描述 特定关节炎的患病率、相关性和潜在决定因素 疾病(目前为骨关节炎和系统性红斑狼疮)或其后遗症；4) 预防战略；5)成果研究；6)教育方案 医生和其他健康专业人员治疗患者的 关节炎。E/E/HSR部分提出了四个项目：“事件” 以及北卡罗来纳州约翰斯顿县膝关节和髋关节骨关节炎的进展“； “关节炎患者与其配偶之间的情感传染”； “风湿性关节炎的自我管理、教育和结果”；以及 “预防类风湿性关节炎妇女骨质疏松症 口服糖皮质激素疗法“。数字科学核心提供： 方法学咨询和审查；发展和维护 患者数据库；数据录入与管理；生物统计咨询； 教育；以及计算机技术。

The Multipurpose Arthritis & Musculoskeletal Diseases Center at the University of North Carolina at Chapel H. chartered by the School of Medicine as the Thurston Arthritis Research Center, consists of a Biomedical Research Component, an Education, Epidemiology, & Health Services Research (E/E/HSR) Component, a Biomolecular Core, a Numerical Sciences Core, and an Administrative Unit. Ongoing and planned investigation in the Biomedical Research component encompasses many of the issues relevant to autoimmunity, arthritis, and musculoskeletal disease: genetics, regulation, and function of recognition elements in normal and abnormal immune responses; peptide/MHC structure function relationships; induction and regulation of cytokine and inflammatory responses genes; the repertoire of T cell receptor and B cell Ig genes and their role in autoimmunity; T cell activation and signal transduction; molecular genetics of autoantibody formation; contribution of autoantibodies to disease pathogenesis; immunosuppression; inciting agents in autoimmunity; inflammation in experimental arthritis and its therapy; biochemistry and cell biology of cartilage; pathophysiology of mechanical joint injury and its relationship to osteoarthritis; clinical investigation of arthritis, osteoporosis, and systemic connective tissue diseases; and mechanisms of pain. Three Development & Feasibility projects are proposed. "Mechanisms of anti-nRNP/Sm autoantibody spreading"; "The role of beta2GPI in apoptosis"; and "Prevention of Arthritis with Dietary Glycine". A Biomolecular Core provides: serological and clinical databases and a cell bank; flow cytometry; and inbred mouse colony; and a biomolecular imaging facility. Research themes in the E/E/HSR Component include: 1) studies aimed at increasing our understanding of how people adapt to and cope with arthritis; 2) development or validation of measurement procedures related to arthritis; 3) epidemiological studies aimed at describing the prevalence, correlates, and potential determinants of specific arthritic disorders (currently osteoarthritis and SLE) or their sequelae; 4) prevention strategies; 5) outcomes research; and 6) education programs for physicians and other health professionals who treat patients with arthritis. Four projects are proposed in the E/E/HSR Component: "Incidence and progression of knee and hip osteoarthritis in Johnston County, NC"; "Emotional contagion between people having arthritis and their spouses"; "Self-management, education and outcomes in rheumatoid arthritis"; and "Osteoporosis prevention among women with rheumatoid arthritis receiving oral glucocorticoid therapy". A Numerical Sciences Core provides: methodological consultation and review; development and maintenance of patient databases; data entry and management; biostatistical consultation; education; and computer technology.